Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 7/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | ITGB2 | P05107 | 4/20 | 0.35 |
| ▸ | ICAM1 | P05362 | 4/20 | 0.35 |
| ▸ | ITGAL | P20701 | 4/20 | 0.35 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.34 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670623 | 0.93 | KARS1 (0.38) | KARS1GSK3BDYRK1ATRPV1ITGB2 | |
| SCHEMBL19670006 | 0.90 | KARS1 (0.40) | KARS1GSK3BDYRK1ATRPV1ITGB2 | |
| SCHEMBL19365434 | 0.89 | VCP (0.41) | KARS1GSK3BDYRK1ATRPV1PTGS1 | |
| SCHEMBL19365436 | 0.89 | VCP (0.41) | KARS1GSK3BDYRK1ATRPV1PTGS1 | |
| SCHEMBL19670226 | 0.87 | CNR2 (0.38) | KARS1GSK3BDYRK1ATRPV1 | |
| SCHEMBL19365483 | 0.87 | KARS1 (0.43) | KARS1GSK3BDYRK1ATRPV1ITGB2 | |
| SCHEMBL19365725 | 0.86 | FGFR4 (0.37) | KARS1ITGB2ICAM1ITGALLRRK2 | |
| SCHEMBL19365721 | 0.86 | FGFR4 (0.37) | KARS1ITGB2ICAM1ITGALLRRK2 | |
| SCHEMBL17618666 | 0.86 | KARS1 (0.41) | KARS1GSK3BDYRK1ATRPV1ITGB2 | |
| SCHEMBL19669052 | 0.86 | KARS1 (0.41) | KARS1GSK3BDYRK1ATRPV1ITGB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |