Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 3/20 | 0.38 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | ITGB2 | P05107 | 9/20 | 0.36 |
| ▸ | ICAM1 | P05362 | 9/20 | 0.36 |
| ▸ | ITGAL | P20701 | 9/20 | 0.36 |
| ▸ | CLK2 | P49760 | 2/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670498 | 0.93 | KARS1 (0.41) | KARS1TRPV1ITGB2ICAM1ITGAL | |
| SCHEMBL19670490 | 0.91 | SLC34A1 (0.36) | KARS1MAP3K12ITGB2ICAM1ITGAL | |
| SCHEMBL19365292 | 0.90 | VCP (0.40) | KARS1MAP3K12TRPV1CLK2LRRK2 | |
| SCHEMBL19670444 | 0.88 | ITGB2 (0.36) | KARS1MAP3K12ITGB2ICAM1ITGAL | |
| SCHEMBL19361174 | 0.87 | KARS1 (0.38) | KARS1MAP3K12TRPV1ITGB2ICAM1 | |
| SCHEMBL19670010 | 0.86 | CLK2 (0.34) | KARS1MAP3K12ITGB2ICAM1ITGAL | |
| SCHEMBL19670375 | 0.86 | TRPV1 (0.41) | TRPV1GSK3BDYRK1AAR | |
| SCHEMBL19670226 | 0.85 | CNR2 (0.38) | KARS1MAP3K12TRPV1GSK3BDYRK1A | |
| SCHEMBL19670006 | 0.84 | KARS1 (0.40) | KARS1TRPV1ITGB2ICAM1ITGAL | |
| SCHEMBL19365276 | 0.84 | WNT3A (0.41) | TRPV1GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |