Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK2 | P49760 | 2/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.33 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 7/20 | 0.32 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.32 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.32 |
| ▸ | ITGAL | P20701 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 2/20 | 0.32 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670490 | 0.88 | SLC34A1 (0.36) | CLK2LRRK2SCN10AKCNH2SCN5A | |
| SCHEMBL19365440 | 0.88 | PIM2 (0.35) | CLK2LRRK2KCNH2SCN5APIM2 | |
| SCHEMBL19361180 | 0.87 | SCN10A (0.37) | CLK2LRRK2SCN10AKCNH2SCN5A | |
| SCHEMBL19670623 | 0.86 | KARS1 (0.38) | CLK2LRRK2KCNH2SCN5AKARS1 | |
| SCHEMBL19670206 | 0.85 | DYRK1A (0.34) | CLK2SCN10AKARS1MAP3K12DYRK1A | |
| SCHEMBL19365752 | 0.85 | WNT3A (0.37) | ABL1DYRK1A | |
| SCHEMBL19670514 | 0.84 | KARS1 (0.34) | KARS1ABL1DYRK1ABRAF | |
| SCHEMBL19670507 | 0.84 | KARS1 (0.34) | KARS1ABL1DYRK1ABRAF | |
| SCHEMBL19670444 | 0.82 | ITGB2 (0.36) | KARS1MAP3K12ITGB2ICAM1ITGAL | |
| SCHEMBL19365369 | 0.82 | GSK3B (0.38) | CLK2KCNH2ABL1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |