Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.37 |
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670268 | 0.97 | JAK2 (0.45) | JAK2JAK3PTK2RAF1BRAF | |
| SCHEMBL17624496 | 0.88 | RAF1 (0.41) | JAK2JAK3PTK2RAF1BRAF | |
| SCHEMBL19670651 | 0.86 | TRPV1 (0.40) | RAB9AMAPTPOLBCYP1A2HTR2A | |
| SCHEMBL17624661 | 0.85 | JAK2 (0.44) | JAK2JAK3PTK2RAF1BRAF | |
| SCHEMBL19670497 | 0.82 | MAPT (0.45) | RAB9AMAPTTRPV1 | |
| SCHEMBL19670299 | 0.78 | FYN (0.43) | MAPTCA2CA9CYP1A2HTR2A | |
| SCHEMBL16785641 | 0.77 | JAK2 (0.44) | JAK2JAK3PTK2RAF1BRAF | |
| SCHEMBL19365574 | 0.77 | CA2 (0.41) | NPC1RAB9AMAPTPOLBCA2 | |
| SCHEMBL19670466 | 0.77 | CA2 (0.41) | NPC1RAB9AMAPTPOLBCA2 | |
| SCHEMBL19699095 | 0.75 | FLT3 (0.38) | CA2CA9TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |