Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | FPR1 | P21462 | 1/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | NPY2R | P49146 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365574 | 1.00 | CA2 (0.41) | CA2CA9FPR1FPR2NPY2R | |
| SCHEMBL19670497 | 0.88 | MAPT (0.45) | LMNAHTTSMN1; SMN2MAPTGAA | |
| SCHEMBL17618793 | 0.86 | NPY2R (0.43) | CA2CA9FPR1FPR2NPY2R | |
| SCHEMBL19670299 | 0.84 | FYN (0.43) | CA2CA9LMNAHTTSMN1; SMN2 | |
| SCHEMBL19365834 | 0.80 | CNR2 (0.51) | LMNATHRBCNR1 | |
| SCHEMBL19670537 | 0.80 | CNR2 (0.51) | LMNATHRBCNR1 | |
| SCHEMBL17624594 | 0.80 | TRPV1 (0.39) | CA2CA9LMNAHTTSMN1; SMN2 | |
| SCHEMBL19365413 | 0.78 | ADCY1 (0.50) | LMNAHTTSMN1; SMN2HSD17B10MEN1 | |
| SCHEMBL19670476 | 0.78 | TRPV1 (0.46) | MAPTTRPV1 | |
| SCHEMBL19670651 | 0.78 | TRPV1 (0.40) | NPY2RMAPTTRPV1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |