Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 12/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | NPY2R | P49146 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | OGG1 | O15527 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17624502 | 0.88 | TRPV1 (0.42) | TRPV1CREBBPCYP1A2HTR2CHTR2A | |
| SCHEMBL19706109 | 0.86 | TRPV1 (0.40) | TRPV1CREBBPCYP1A2HTR2CHTR2A | |
| SCHEMBL19670544 | 0.86 | JAK2 (0.42) | TRPV1CYP1A2HTR2CHTR2ARAB9A | |
| SCHEMBL19670268 | 0.86 | JAK2 (0.45) | TRPV1CYP1A2HTR2CHTR2ARAB9A | |
| SCHEMBL19670497 | 0.82 | MAPT (0.45) | TRPV1RAB9AMAPT | |
| SCHEMBL16785656 | 0.82 | CREBBP (0.42) | TRPV1CREBBPCYP1A2HTR2CHTR2A | |
| SCHEMBL19670466 | 0.78 | CA2 (0.41) | TRPV1NPY2RRAB9APOLBMAPT | |
| SCHEMBL19365574 | 0.78 | CA2 (0.41) | TRPV1NPY2RRAB9APOLBMAPT | |
| SCHEMBL12806233 | 0.78 | KDM1A (0.41) | POLB | |
| SCHEMBL19670299 | 0.78 | FYN (0.43) | TRPV1CYP1A2HTR2CHTR2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |