Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 7/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.39 |
| ▸ | GPR142 | Q7Z601 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19706003 | 0.89 | HDAC3 (0.40) | NOTUMAURKAAURKBGPR142ALK | |
| SCHEMBL19865067 | 0.87 | NOTUM (0.47) | NOTUMAURKAAURKBGPR142ALK | |
| SCHEMBL16238555 | 0.86 | NOTUM (0.46) | NOTUMAURKAAURKBGPR142MAPT | |
| SCHEMBL19365904 | 0.84 | MAPT (0.43) | MAPTNPC1SMN1; SMN2MCHR1 | |
| Trifluoroacetic Acid SCHEMBL16238799 | 0.83 | NOTUM (0.44) | NOTUMAURKAAURKBGPR142MAPT | |
| SCHEMBL19706043 | 0.81 | FYN (0.38) | MAPTNPC1SMN1; SMN2MCHR1 | |
| SCHEMBL19365254 | 0.81 | HTR2C (0.47) | MAPTNPC1SMN1; SMN2 | |
| SCHEMBL19365708 | 0.80 | MAPT (0.41) | MAPTMAOAMAOBNPC1SMN1; SMN2 | |
| SCHEMBL19365568 | 0.80 | RHOA (0.50) | MAPT | |
| SCHEMBL19670464 | 0.80 | MAPT (0.40) | MAPTNPC1SMN1; SMN2MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |