Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | RHOA | P61586 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365904 | 0.88 | MAPT (0.43) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL16776084 | 0.85 | GRIN2B (0.38) | MAPTMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL19365254 | 0.85 | HTR2C (0.47) | MAPTMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL19365708 | 0.84 | MAPT (0.41) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL19365568 | 0.84 | RHOA (0.50) | MAPTMEN1KMT2AALDH1A1FYN | |
| SCHEMBL16238556 | 0.84 | IDH2 (0.40) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL17618579 | 0.83 | IDH2 (0.41) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL20632111 | 0.83 | MAPT (0.46) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL19365595 | 0.82 | MAPT (0.38) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL19670411 | 0.81 | MAPT (0.41) | MAPTALDH1A1SMN1; SMN2NPC1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |