Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 3/20 | 0.37 |
| ▸ | LCK | P06239 | 2/20 | 0.37 |
| ▸ | SRC | P12931 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365254 | 0.92 | HTR2C (0.47) | MAPTKITHTR2AHTR2CMEN1 | |
| SCHEMBL19365595 | 0.91 | MAPT (0.38) | MAPTCA2CA9DHODHHTR2A | |
| SCHEMBL19365904 | 0.91 | MAPT (0.43) | MAPTCA2CA9FYNMEN1 | |
| SCHEMBL19365498 | 0.87 | HTR2C (0.46) | MAPTKITHTR2AHTR2CMEN1 | |
| SCHEMBL19670418 | 0.86 | MPL (0.42) | MAPTCA2CA9FYNKDM1A | |
| SCHEMBL19365468 | 0.86 | CA2 (0.39) | MAPTCA2CA9KDRMEN1 | |
| SCHEMBL19865057 | 0.86 | RHOA (0.41) | MAPTCA2CA9HTR2CFYN | |
| SCHEMBL19365457 | 0.86 | MAPT (0.38) | MAPTCA2CA9DHODHKIT | |
| SCHEMBL12959003 | 0.85 | HTR2C (0.44) | MAPTCA2CA9DHODHKIT | |
| SCHEMBL19365368 | 0.85 | TRPA1 (0.38) | MAPTCA2CA9KDM1AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |