Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOA | P61586 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.39 |
| ▸ | CCKAR | P32238 | 1/20 | 0.39 |
| ▸ | CCKBR | P32239 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365904 | 0.89 | MAPT (0.43) | MAPTLMNAFYNMEN1ALDH1A1 | |
| SCHEMBL16776294 | 0.86 | RHOA (0.48) | RHOAMAPTOTUD7BLMNAMAPK1 | |
| SCHEMBL17618773 | 0.86 | RHOA (0.51) | RHOAMAPTOTUD7BLMNAMAPK1 | |
| SCHEMBL19365254 | 0.85 | HTR2C (0.47) | MAPTMEN1KMT2A | |
| SCHEMBL19365708 | 0.85 | MAPT (0.41) | MAPTFYNMEN1ALDH1A1KMT2A | |
| SCHEMBL19670464 | 0.84 | MAPT (0.40) | RHOAMAPTLMNAFYNMEN1 | |
| SCHEMBL20632111 | 0.84 | MAPT (0.46) | MAPTLMNAFYNMEN1ALDH1A1 | |
| SCHEMBL19670243 | 0.83 | KDM1A (0.38) | MAPTFYNMEN1ALDH1A1KMT2A | |
| SCHEMBL19670583 | 0.83 | KMT2A (0.39) | RHOAMAPTMAPK1FYNMEN1 | |
| SCHEMBL19365595 | 0.83 | MAPT (0.38) | MAPTLMNAMAPK1FYNMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |