Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 3/20 | 0.37 |
| ▸ | SCD | O00767 | 1/20 | 0.36 |
| ▸ | MLNR | O43193 | 2/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670388 | 0.88 | CACNA1G (0.46) | — | |
| SCHEMBL19670253 | 0.88 | MLLT1 (0.38) | MLNRCNR1 | |
| SCHEMBL19670174 | 0.87 | HDAC2 (0.39) | MLNRPDK1PDK2PDK3PDK4 | |
| SCHEMBL19670172 | 0.86 | ADORA2A (0.37) | MLNRPDK1PDK2PDK3PDK4 | |
| SCHEMBL19670590 | 0.84 | IRAK4 (0.41) | METUSP30BRD4 | |
| SCHEMBL19670252 | 0.84 | THRB (0.38) | MLNRPDK1PDK2PDK3PDK4 | |
| SCHEMBL19670170 | 0.84 | BRAF (0.40) | PDK1PDK2PDK3PDK4MTOR | |
| SCHEMBL19670512 | 0.84 | BTK (0.37) | RPS6KA2 | |
| SCHEMBL16775989 | 0.83 | RPS6KA3 (0.41) | JAK1JAK3METSCDMLNR | |
| SCHEMBL19670241 | 0.83 | GRM5 (0.38) | PDK1PDK2PDK3PDK4MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |