Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.36 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670589 | 0.88 | HTR2C (0.42) | FYNABL1 | |
| SCHEMBL19670386 | 0.88 | CACNA1H (0.37) | IRAK4FYNTRPA1KDRBRD4 | |
| SCHEMBL19670428 | 0.85 | ABL1 (0.40) | IRAK4FYNABL1KCNH2SLC5A1 | |
| SCHEMBL19670593 | 0.84 | JAK1 (0.38) | METUSP30BRD4 | |
| SCHEMBL19670238 | 0.83 | TRPA1 (0.38) | IRAK4FYNTRPA1ABL1KDR | |
| SCHEMBL19670164 | 0.83 | GSK3B (0.40) | IRAK4KDRSLC5A1PIM1 | |
| SCHEMBL19670385 | 0.83 | MPL (0.44) | IRAK4FYNTRPA1SLC5A1USP30 | |
| SCHEMBL17618472 | 0.83 | IRAK4 (0.42) | IRAK4METFYNABL1KCNH2 | |
| SCHEMBL19670257 | 0.82 | HPGDS (0.38) | IRAK4SLC5A1PIM1 | |
| SCHEMBL19670512 | 0.82 | BTK (0.37) | CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |