Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1G | O43497 | 4/20 | 0.46 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.46 |
| ▸ | CACNA1I | Q9P0X4 | 4/20 | 0.46 |
| ▸ | HTR2A | P28223 | 4/20 | 0.41 |
| ▸ | HTR2C | P28335 | 4/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | PRKCA | P17252 | 1/20 | 0.39 |
| ▸ | TEK | Q02763 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670174 | 0.90 | HDAC2 (0.39) | CACNA1GCACNA1HCACNA1I | |
| SCHEMBL19670252 | 0.89 | THRB (0.38) | CACNA1GCACNA1HCACNA1ITHRB | |
| SCHEMBL19670593 | 0.88 | JAK1 (0.38) | — | |
| SCHEMBL19670170 | 0.87 | BRAF (0.40) | CACNA1GCACNA1HCACNA1IBRAFTHRB | |
| SCHEMBL19670393 | 0.86 | ABL1 (0.42) | CACNA1GCACNA1HCACNA1IHTR2AHTR2C | |
| SCHEMBL19670179 | 0.86 | HTR2C (0.46) | CACNA1GCACNA1HCACNA1IHTR2AHTR2C | |
| SCHEMBL19670241 | 0.86 | GRM5 (0.38) | — | |
| SCHEMBL19865050 | 0.85 | HTR2C (0.40) | CACNA1GCACNA1HCACNA1IHTR2AHTR2C | |
| SCHEMBL19670253 | 0.85 | MLLT1 (0.38) | CACNA1H | |
| SCHEMBL19670589 | 0.84 | HTR2C (0.42) | CACNA1GCACNA1HCACNA1IHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |