Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 4/20 | 0.36 |
| ▸ | BRAF | P15056 | 4/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | PLG | P00747 | 2/20 | 0.35 |
| ▸ | PLAU | P00749 | 2/20 | 0.35 |
| ▸ | PLAT | P00750 | 2/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20633162 | 0.87 | AURKA (0.38) | RAF1KDM1AFYNCSF1RKIT | |
| SCHEMBL20633441 | 0.87 | FYN (0.39) | CA2CA9RAF1BRAFKDM1A | |
| SCHEMBL20633005 | 0.87 | LMNA (0.38) | RAF1BRAFKDM1AFYNMAPT | |
| SCHEMBL19670654 | 0.86 | CA2 (0.42) | CA2CA9CFTRPLGPLAU | |
| SCHEMBL20632922 | 0.85 | KDM4E (0.36) | CA2CA9KDM1AFYNCSF1R | |
| SCHEMBL20632643 | 0.84 | CSF1R (0.38) | RAF1BRAFKDM1AFYNCSF1R | |
| SCHEMBL20632046 | 0.84 | CYP1A2 (0.43) | CA2CA9BRAFFYNCSF1R | |
| SCHEMBL20632070 | 0.84 | BRAF (0.34) | RAF1BRAFFYNCSF1RKIT | |
| SCHEMBL20633233 | 0.83 | KMT2A (0.36) | KDM1AFYNKDM4EALDH1A1ADORA2A | |
| SCHEMBL20631589 | 0.83 | PHGDH (0.35) | CA2CA9RAF1BRAFKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |