Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.60 |
| ▸ | LMNA | P02545 | 5/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22749233 | 0.89 | SMN1; SMN2 (0.60) | ALDH1A1LMNAMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL5215761 | 0.85 | ALOX15 (0.52) | ALDH1A1LMNANPC1RAB9AMAPT | |
| SCHEMBL13411081 | 0.80 | LMNA (0.51) | ALDH1A1LMNANPC1RAB9AMAPT | |
| SCHEMBL5216679 | 0.78 | SMN1; SMN2 (0.49) | ALDH1A1LMNANPC1RAB9AALOX15 | |
| SCHEMBL5219357 | 0.78 | HTR4 (0.50) | ALDH1A1LMNANPC1RAB9AMAPT | |
| SCHEMBL1516954 | 0.78 | ALDH1A1 (0.50) | ALDH1A1LMNANPC1RAB9AMAPT | |
| SCHEMBL3377958 | 0.76 | TP53 (0.61) | ALDH1A1MAPTHTTSMN1; SMN2GAA | |
| SCHEMBL8263028 | 0.76 | ALDH1A1 (0.60) | ALDH1A1LMNANPC1RAB9AMAPT | |
| SCHEMBL5368854 | 0.75 | MEN1 (0.61) | ALDH1A1LMNASMN1; SMN2GAAMEN1 | |
| SCHEMBL5215957 | 0.75 | SMN1; SMN2 (0.60) | ALDH1A1LMNANPC1MAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2914597-B1 | PYRAZOLOPYRIDINE DERIVATIVES AS TTX-S BLOCKERS | RAQUALIA PHARMA INC (JP) | 2017-12-06 | — | — | EP | disclosed |