Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14712149 | 0.85 | ALDH1A1 (0.53) | ABL1RIN1ALDH1A1GAAGFER | |
| SCHEMBL31053221 | 0.83 | RAB9A (0.46) | ABL1RIN1ALDH1A1KMT2AMEN1 | |
| SCHEMBL20773247 | 0.83 | RAB9A (0.46) | ABL1RIN1ALDH1A1KMT2AMEN1 | |
| SCHEMBL849433 | 0.81 | CA2 (0.47) | ABL1RIN1ALDH1A1GAAKMT2A | |
| SCHEMBL1725721 | 0.81 | MTNR1A (0.45) | ABL1RIN1ALDH1A1GAAGFER | |
| SCHEMBL5239543 | 0.79 | POLB (0.44) | ABL1RIN1ALDH1A1GAAKMT2A | |
| SCHEMBL4944685 | 0.79 | KDM4E (0.50) | ALDH1A1GAAKMT2AMEN1MAPT | |
| SCHEMBL30354606 | 0.79 | KDM4E (0.50) | ALDH1A1GAAKMT2AMEN1MAPT | |
| SCHEMBL18524342 | 0.75 | ALDH1A1 (0.53) | ABL1RIN1ALDH1A1GAAGFER | |
| SCHEMBL19675576 | 0.74 | L3MBTL1 (0.49) | ALDH1A1KMT2AMEN1L3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3252050-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-12-06 | — | — | EP | disclosed |
| EP-3252049-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-12-06 | — | — | EP | disclosed |