Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PCNA | P12004 | 10/20 | 0.62 |
| ▸ | THRB | P10828 | 8/20 | 0.62 |
| ▸ | THRA | P10827 | 6/20 | 0.62 |
| ▸ | PPARG | P37231 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | POLB | P06746 | 3/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.62 |
| ▸ | RXRA | P19793 | 2/20 | 0.62 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.62 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.62 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.62 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | PGR | P06401 | 1/20 | 0.62 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.62 |
| ▸ | HTR1A | P08908 | 1/20 | 0.62 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19679561 | 0.91 | PCNA (0.55) | PCNATHRBTHRAPPARGLMNA | |
| SCHEMBL1814819 | 0.86 | THRB (0.66) | PCNATHRBTHRAPPARGLMNA | |
| SCHEMBL19679558 | 0.81 | THRB (0.62) | PCNATHRBTHRAPPARGLMNA | |
| SCHEMBL12764506 | 0.78 | THRB (0.57) | PCNATHRBTHRAPPARGLMNA | |
| Tiratricol SCHEMBL743426 | 0.77 | THRB (1.00) | PCNATHRBTHRAPPARGLMNA | |
| Tiratricol SCHEMBL30161572 | 0.77 | THRB (1.00) | PCNATHRBTHRAPPARGLMNA | |
| Tiratricol SCHEMBL25149 | 0.77 | THRB (1.00) | PCNATHRBTHRAPPARGLMNA | |
| SCHEMBL6858155 | 0.76 | THRB (0.70) | PCNATHRBTHRAPPARGLMNA | |
| Tiratricol SCHEMBL2671904 | 0.76 | THRB (0.97) | PCNATHRBTHRAPPARGLMNA | |
| Tiratricol SCHEMBL8660328 | 0.76 | THRB (0.97) | PCNATHRBTHRAPPARGLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170348425-A1 | NON-CLEAVABLE POLYMER CONJUGATED WITH ALPHA V BETA 3 INTEGRIN THYROID ANTAGONISTS | NANOPHARMACEUTICALS, LLC | 2017-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170348425-A1 | NON-CLEAVABLE POLYMER CONJUGATED WITH ALPHA V BETA 3 INTEGRIN THYROID ANTAGONISTS | THRA, CD44, ITGAV | PCNA 2561/4885THRB 5/4885THRA 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.