SCHEMBL19681283

SCHEMBL19681283

CC(=O)N1CCCC1C(=O)NCCCCC(NC(=O)C1CCCN1C(=O)Cl)C(=O)NCCN

nearest known ligand 0.44

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
APLNR P35414 1/20 0.44
MMP3 P08254 4/20 0.44
MMP1 P03956 1/20 0.44
F2 P00734 1/20 0.42
SIRT6 Q8N6T7 1/20 0.42
SIRT1 Q96EB6 1/20 0.42
ITGB3 P05106 3/20 0.41
ITGA2B P08514 3/20 0.41
NTMT1 Q9BV86 2/20 0.41
OPRM1 P35372 2/20 0.39
NPFFR1 Q9GZQ6 2/20 0.39
NPFFR2 Q9Y5X5 2/20 0.39
OPRD1 P41143 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
MMP2 P08253 2/20 0.39
P2RX7 Q99572 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19681209 0.96 NTMT1 (0.43) APLNRMMP3MMP1SIRT6SIRT1
SCHEMBL19681207 0.96 MMP3 (0.46) APLNRMMP3MMP1F2SIRT6
SCHEMBL19681253 0.91 SIRT6 (0.52) APLNRMMP3MMP1F2SIRT6
SCHEMBL19681264 0.86 POLB (0.44) APLNRMMP3MMP1F2SIRT6
SCHEMBL21167022 0.86 APLNR (0.46) APLNRMMP3MMP1F2SIRT6
SCHEMBL21705523 0.86 APLNR (0.53) APLNRMMP3MMP1SIRT6SIRT1
SCHEMBL21351094 0.85 MMP3 (0.46) APLNRMMP3MMP1F2SIRT6
SCHEMBL21705592 0.85 MMP3 (0.47) APLNRMMP3MMP1F2SIRT6
SCHEMBL20370188 0.85 MMP3 (0.46) APLNRMMP3MMP1F2OPRM1
SCHEMBL21166938 0.84 MMP1 (0.53) APLNRMMP3MMP1F2ITGB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10548952-B2 Injectable solution at pH7 comprising at least one basal insulin the pI of which is from 5.8 to 8.5, a prandial insulin and/or a gastrointestinal hormone, and a co-polyamino acid bearing carboxylate charges and hydrophobic radicals ADOCIA (FR) 2020-02-04 US disclosed
US-20170348396-A1 Injectable solution at pH7 comprising at least one basal insulin the pI of which is from 5.8 to 8.5, a prandial insulin and/or a gastrointestinal hormone, and a co-polyamino acid bearing carboxylate charges and hydrophobic radicals ADOCIA (FR) 2017-12-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170348396-A1 Injectable solution at pH7 comprising at least one basal insulin the pI of which is from 5.8 to 8.5, a prandial insulin and/or a gastrointestinal hormone, and a co-polyamino acid bearing carboxylate charges and hydrophobic radicals IAPP, F7, GIPR APLNR 1129/4885MMP3 1553/4885MMP1 352/4885
US-10548952-B2 Injectable solution at pH7 comprising at least one basal insulin the pI of which is from 5.8 to 8.5, a prandial insulin and/or a gastrointestinal hormone, and a co-polyamino acid bearing carboxylate charges and hydrophobic radicals IAPP, F7, GIPR APLNR 1129/4885MMP3 1553/4885MMP1 352/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.