SCHEMBL19682579

SCHEMBL19682579

C[C@H](c1cccc2cccc(F)c12)[C@H](N)C(=O)O

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
DPP7 Q9UHL4 3/20 0.39
DPP4 P27487 1/20 0.39
SLC1A1 P43005 3/20 0.35
GAA P10253 3/20 0.35
KDM4E B2RXH2 1/20 0.35
CASP1 P29466 1/20 0.35
CASP7 P55210 1/20 0.35
KMT2A Q03164 1/20 0.35
AKR1C3 P42330 1/20 0.35
AKR1C2 P52895 1/20 0.35
SLC1A3 P43003 1/20 0.33
SLC1A2 P43004 1/20 0.33
LMNA P02545 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
ALDH1A1 P00352 1/20 0.33
SLC7A5 Q01650 1/20 0.33
ALOX5 P09917 1/20 0.33
DPP8 Q6V1X1 2/20 0.33
DPP9 Q86TI2 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20889259 1.00 DPP7 (0.39) DPP7DPP4SLC1A1GAAKDM4E
SCHEMBL22507743 1.00 DPP7 (0.39) DPP7DPP4SLC1A1GAAKDM4E
SCHEMBL19682746 0.83 SLC1A3 (0.38) SLC1A1GAAKDM4ECASP1CASP7
SCHEMBL20889360 0.83 SLC1A3 (0.38) SLC1A1GAAKDM4ECASP1CASP7
SCHEMBL20889267 0.83 CES2 (0.45) DPP7DPP4SLC1A1GAASLC1A3
SCHEMBL19682604 0.83 CES2 (0.45) DPP7DPP4SLC1A1GAASLC1A3
SCHEMBL19682597 0.81 DPP7 (0.40) DPP7DPP4SLC1A1GAAAKR1C3
SCHEMBL20889385 0.81 DPP7 (0.40) DPP7DPP4SLC1A1GAAAKR1C3
SCHEMBL11816527 0.81 AKR1C3 (0.43) GAAKDM4ECASP1CASP7KMT2A
SCHEMBL20889384 0.80 DPP4 (0.39) DPP7DPP4SLC1A1GAAAKR1C3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10889555-B2 Sulfonamide compound or salt thereof TAIHO PHARMACEUTICAL CO., LTD. (JP) 2021-01-12 US disclosed
US-20200405697-A1 Antitumor Agent TAIHO PHARMACEUTICAL CO., LTD. (JP) 2020-12-31 US disclosed
US-20200399235-A1 Sulfonamide Compound or Salt Thereof TAIHO PHARMACEUTICAL CO., LTD. (JP) 2020-12-24 US disclosed
EP-3718545-A1 ANTITUMOR AGENT Taiho Pharmaceutical Co., Ltd. (JP) 2020-10-07 EP disclosed
US-20200157066-A1 Sulfonamide Compound or Salt Thereof TAIHO PHARMACEUTICAL CO., LTD. (JP) 2020-05-21 US disclosed
EP-3466934-A1 SULFONAMIDE COMPOUND OR SALT THEREOF Taiho Pharmaceutical Co., Ltd. (JP) 2019-04-10 EP disclosed
WO-2017209155-A1 SULFONAMIDE COMPOUND OR SALT THEREOF 大鵬薬品工業株式会社 2017-12-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200399235-A1 Sulfonamide Compound or Salt Thereof RNASEH1, SNRPA1, RRM2 DPP7 3961/4885DPP4 3280/4885SLC1A1 3403/4885
US-20200157066-A1 Sulfonamide Compound or Salt Thereof RNASEH1, SNRPA1, RRM2 DPP7 3961/4885DPP4 3280/4885SLC1A1 3403/4885
US-10889555-B2 Sulfonamide compound or salt thereof RNASEH1, SNRPA1, RRM2 DPP7 3961/4885DPP4 3280/4885SLC1A1 3403/4885
US-20200405697-A1 Antitumor Agent HNRNPR, RRM2, RRM2B DPP7 4703/4885DPP4 4367/4885SLC1A1 3066/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.