Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 9/20 | 0.53 |
| ▸ | EGLN3 | Q9H6Z9 | 6/20 | 0.53 |
| ▸ | EGLN2 | Q96KS0 | 4/20 | 0.53 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1965654 | 0.86 | EGLN1 (0.51) | EGLN1EGLN3EGLN2HIF1A | |
| SCHEMBL1968792 | 0.86 | EGLN1 (0.40) | EGLN1EGLN3EGLN2HDAC1HDAC8 | |
| SCHEMBL1968417 | 0.85 | EGLN3 (0.44) | EGLN1EGLN3EGLN2HIF1AHDAC1 | |
| SCHEMBL1963992 | 0.84 | KDM4E (0.45) | EGLN1EGLN3EGLN2HDAC1HDAC8 | |
| SCHEMBL3730753 | 0.82 | EGLN1 (0.53) | EGLN1EGLN3EGLN2CYSLTR2HIF1A | |
| SCHEMBL1967789 | 0.73 | EGLN1 (0.44) | EGLN1EGLN3EGLN2HIF1A | |
| SCHEMBL1586296 | 0.73 | EGLN1 (0.53) | EGLN1EGLN3EGLN2CYSLTR2HIF1A | |
| SCHEMBL1967018 | 0.73 | L3MBTL1 (0.44) | EGLN1 | |
| SCHEMBL8244832 | 0.72 | EGLN1 (0.81) | EGLN1EGLN3EGLN2CYSLTR2HIF1A | |
| SCHEMBL3731074 | 0.72 | EGLN3 (0.51) | EGLN1EGLN3EGLN2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334682-A1 | PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS | Fibrogen, Inc. (US) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010022240-A1 | PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS | FIBROGEN, INC. (US) | 2010-02-25 | — | — | WO | disclosed |