Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 9/20 | 0.43 |
| ▸ | IDH1 | O75874 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.38 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19684403 | 0.93 | ELANE (0.47) | ELANEIDH1CYP3A4CYP2C9AURKA | |
| SCHEMBL19684522 | 0.83 | ELANE (0.48) | ELANEIDH1AURKAMAPTRXFP1 | |
| SCHEMBL19684419 | 0.82 | ELANE (0.48) | ELANEIDH1AURKAMAPTRXFP1 | |
| SCHEMBL19688572 | 0.81 | BRAF (0.37) | ELANEIDH1BRAFGAAMAPT | |
| SCHEMBL19684417 | 0.76 | UBE2M (0.42) | ELANEAURKASMN1; SMN2MEN1KMT2A | |
| SCHEMBL19684414 | 0.76 | ELANE (0.41) | ELANEIDH1AURKARXFP1MEN1 | |
| SCHEMBL19640137 | 0.75 | ELANE (0.46) | ELANEIDH1CYP3A4CYP2C9AURKA | |
| SCHEMBL19640095 | 0.74 | ELANE (0.49) | ELANEIDH1AURKAMAPTRXFP1 | |
| SCHEMBL19640079 | 0.73 | ELANE (0.47) | ELANEIDH1CYP2C9AURKAGAA | |
| SCHEMBL19640140 | 0.71 | ELANE (0.43) | ELANECYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017207432-A1 | NOVEL COMPOUNDS | CHIESI FARMACEUTICI S.P.A. (IT) | 2017-12-07 | — | — | WO | disclosed |