Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.42 |
| ▸ | IDH1 | O75874 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.40 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.40 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.40 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.40 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19684419 | 0.94 | ELANE (0.48) | ELANEAURKARXFP1IDH1KCNJ6 | |
| SCHEMBL19684403 | 0.90 | ELANE (0.47) | ELANEAURKARXFP1IDH1MAPT | |
| SCHEMBL19684417 | 0.86 | UBE2M (0.42) | ELANEAURKANPC1SMN1; SMN2EPHX2 | |
| SCHEMBL19684414 | 0.84 | ELANE (0.41) | ELANEAURKARXFP1IDH1KCNJ6 | |
| SCHEMBL19684412 | 0.83 | ELANE (0.43) | ELANEAURKARXFP1IDH1MAPT | |
| SCHEMBL19684716 | 0.83 | MAPT (0.43) | ELANEAURKARXFP1IDH1PTPN1 | |
| SCHEMBL19640095 | 0.78 | ELANE (0.49) | ELANEAURKARXFP1IDH1MAPT | |
| SCHEMBL19640079 | 0.78 | ELANE (0.47) | ELANEAURKARXFP1IDH1KCNJ6 | |
| SCHEMBL19688572 | 0.77 | BRAF (0.37) | ELANEIDH1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL19640137 | 0.76 | ELANE (0.46) | ELANEAURKARXFP1IDH1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017207432-A1 | NOVEL COMPOUNDS | CHIESI FARMACEUTICI S.P.A. (IT) | 2017-12-07 | — | — | WO | disclosed |