Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 17/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PSMB1 | P20618 | 3/20 | 0.41 |
| ▸ | PSMB2 | P49721 | 3/20 | 0.41 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.41 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.41 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.41 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.41 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.41 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.41 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.41 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.41 |
| ▸ | PSMA5 | P28066 | 1/20 | 0.41 |
| ▸ | PSMB4 | P28070 | 1/20 | 0.41 |
| ▸ | PSMB6 | P28072 | 1/20 | 0.41 |
| ▸ | LONP1 | P36776 | 1/20 | 0.41 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.41 |
| ▸ | PSMB3 | P49720 | 1/20 | 0.41 |
| ▸ | PSMA6 | P60900 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3149025 | 0.91 | PSMB5 (0.51) | PSMB5CYP3A4CYP2C19PSMB1PSMB2 | |
| SCHEMBL19387845 | 0.85 | PSMB5 (0.70) | PSMB5PSMB1PSMB2PSMB11PSMA7 | |
| SCHEMBL3149386 | 0.76 | PSMB5 (0.72) | PSMB5PSMB1PSMB2PSMB11PSMA7 | |
| SCHEMBL19387801 | 0.75 | PSMB5 (0.45) | PSMB5PSMB1PSMB2PSMB11PSMA7 | |
| SCHEMBL19687309 | 0.74 | ALDH1A1 (0.42) | PSMB5PSMB1PSMB2PSMB11PSMA7 | |
| SCHEMBL19387844 | 0.73 | F2 (0.44) | PSMB5PSMB1PSMB2PSMB11PSMA7 | |
| SCHEMBL3148972 | 0.72 | NPY5R (0.56) | PSMB5PSMB1PSMB2PSMB11PSMA7 | |
| SCHEMBL13380914 | 0.70 | PSMB5 (0.49) | PSMB5PSMB1PSMB2PSMB11PSMA7 | |
| SCHEMBL3139093 | 0.69 | PSMB5 (0.56) | PSMB5PSMB1PSMB2PSMB11PSMA7 | |
| SCHEMBL3143980 | 0.69 | PSMB5 (0.46) | PSMB5PSMB1PSMB2PSMB11PSMA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10035811-B2 | Derivatives of 1-amino-2-cyclobutylethylboronic acid | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2018-07-31 | — | — | US | disclosed |
| US-20170349611-A1 | DERIVATIVES OF 1-AMINO-2-CYCLOBUTYLETHYLBORONIC ACID | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10035811-B2 | Derivatives of 1-amino-2-cyclobutylethylboronic acid | PSMB6, PSMB5, PSMB1 | PSMB5 2/4885CYP3A4 4412/4885CYP2C19 3951/4885 |
| US-20170349611-A1 | DERIVATIVES OF 1-AMINO-2-CYCLOBUTYLETHYLBORONIC ACID | PSMB6, PSMB5, PSMB1 | PSMB5 2/4885CYP3A4 4412/4885CYP2C19 3951/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.