SCHEMBL196873

SCHEMBL196873

Clc1cccc2ncccc12

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.58
KDM4E B2RXH2 3/20 0.58
CYP1A2 P05177 3/20 0.52
CYP2A6 P11509 2/20 0.52
PABPC1 P11940 2/20 0.51
EIF4H Q15056 2/20 0.51
MEN1 O00255 4/20 0.50
KMT2A Q03164 4/20 0.50
ALDH1A1 P00352 3/20 0.50
L3MBTL1 Q9Y468 2/20 0.50
CYP2C9 P11712 1/20 0.50
HPGD P15428 1/20 0.50
ALOX15 P16050 1/20 0.50
CYP2C19 P33261 1/20 0.50
HSD17B10 Q99714 1/20 0.50
MAPK1 P28482 1/20 0.50
POLB P06746 1/20 0.48
LMNA P02545 4/20 0.47
HSP90AA1 P07900 2/20 0.47
BRD4 O60885 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14127360 1.00 MAPT (0.58) MAPTKDM4ECYP1A2CYP2A6PABPC1
SCHEMBL29971960 1.00 MAPT (0.58) MAPTKDM4ECYP1A2CYP2A6PABPC1
SCHEMBL4004887 0.98 MAPT (0.56) MAPTKDM4ECYP1A2CYP2A6PABPC1
Boric Acid SCHEMBL21047561 0.92 MAPT (0.50) MAPTKDM4ECYP1A2CYP2A6PABPC1
Glyoxylate SCHEMBL27986142 0.84 PABPC1 (0.51) MAPTKDM4ECYP1A2PABPC1EIF4H
SCHEMBL29566907 0.84 MAPT (0.56) MAPTKDM4ECYP1A2CYP2A6MEN1
SCHEMBL201545 0.84 MAPT (0.56) MAPTKDM4ECYP1A2CYP2A6MEN1
Fluoroacetate SCHEMBL27765257 0.83 PABPC1 (0.53) MAPTKDM4ECYP1A2PABPC1EIF4H
Ammonia Solution, Strong SCHEMBL2421811 0.82 MAPT (0.55) MAPTKDM4ECYP1A2CYP2A6MEN1
SCHEMBL4471031 0.82 MAPT (0.55) MAPTKDM4ECYP1A2CYP2A6MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 324 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114105984-B Method for preparing indolizine type corrosion inhibitor 中国石油大学(华东) 2023-08-25 CN claimed
CN-114105984-A Preparation method of indolizine corrosion inhibitor 中国石油大学(华东) 2022-03-01 CN claimed
US-10224485-B2 Process for preparing a crystalline organic semiconductor material BASF SE (DE) 2019-03-05 US claimed
EP-2955173-B1 1,2-BIS-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS ALLERGAN INC (US) 2017-10-04 EP claimed
US-9603834-B2 1,2- bis-sulfonamide derivatives as chemokine receptor modulators ALLERGAN, INC. (US) 2017-03-28 US claimed
US-20170012208-A1 ORGANIC SEMICONDUCTOR FORMULATIONS USINVEST LLC 2017-01-12 US claimed
US-20160228407-A1 NOVEL 1,2- BIS-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS ALLERGAN, INC. 2016-08-11 US claimed
EP-2955173-A1 NOVEL 1,2-BIS-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS ALLERGAN, INC. (US) 2015-12-16 EP claimed
EP-2651901-B1 NOVEL 1,2- BIS-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS ALLERGAN INC (US) 2015-05-27 EP claimed
US-20140221351-A1 NOVEL 1,2- BIS-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS ALLERGAN, INC. (US) 2014-08-07 US claimed
US-7220414-B2 Degradable polyacetal polymers A.P. PHARMA, INC. (US) 2007-05-22 US claimed
EP-1701741-A2 COMPLEXES HAVING ADJUVANT ACTIVITY Polytherics Limited (GB) 2006-09-20 EP claimed
WO-2005065712-A2 COMPLEXES HAVING ADJUVANT ACTIVITY POLYTHERICS LIMITED (GB) 2005-07-21 WO claimed
EP-1210093-A4 DEGRADABLE POLYMERS POLYTHERICS LTD (GB) 2005-01-12 EP claimed
US-6828412-B1 Degradable polymers SCHOOL OF PHARMACY, UNIVERSITY OF LONDON (GB) 2004-12-07 US claimed
EP-1418811-A1 SELECTIVE HERBICIDES BASED ON SUBSTITUTED CYCLIC KETO-ENOLS AND SAFENERS Bayer CropScience AG (DE) 2004-05-19 EP claimed
WO-2003013249-A1 SELECTIVE HERBICIDES BASED ON SUBSTITUTED CYCLIC KETO-ENOLS AND SAFENERS BAYER CROPSCIENCE AG (DE) 2003-02-20 WO claimed
EP-1210093-A1 DEGRADABLE POLYMERS SCHOOL OF PHARMACY, UNIVERSITY OF LONDON (GB) 2002-06-05 EP claimed
WO-2001017515-A1 DEGRADABLE POLYMERS SCHOOL OF PHARMACY, UNIVERSITY OF LONDON (GB) 2001-03-15 WO claimed
US-4795621-A CATALYST OF QUINOLINE COMPOUND AND METAL COMPOUND SHIN NISSO KAKO CO., LTD. (JP) 1989-01-03 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160228407-A1 NOVEL 1,2- BIS-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS CXCR2, CCR2, CX3CR1 MAPT 4542/4885KDM4E 4794/4885CYP1A2 3836/4885
US-20140221351-A1 NOVEL 1,2- BIS-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS CXCR2, CCR2, CX3CR1 MAPT 4542/4885KDM4E 4794/4885CYP1A2 3836/4885
US-10224485-B2 Process for preparing a crystalline organic semiconductor material STOM, SPOP, TTR MAPT 150/4885KDM4E 3646/4885CYP1A2 2553/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.