SCHEMBL19688780

SCHEMBL19688780

C=C(CC(=O)OCC)N(c1cccc(C(F)(F)F)c1)N(C)C(=O)CC

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.42
THRB P10828 1/20 0.40
HPGD P15428 2/20 0.39
CYP1A2 P05177 2/20 0.39
CYP2C19 P33261 2/20 0.39
F2 P00734 1/20 0.39
CYP2C9 P11712 1/20 0.39
HTT P42858 1/20 0.39
ALDH1A1 P00352 4/20 0.39
XPO1 O14980 1/20 0.38
HDAC1 Q13547 1/20 0.38
HDAC8 Q9BY41 1/20 0.38
HDAC6 Q9UBN7 1/20 0.38
GAA P10253 3/20 0.38
ALOX12 P18054 2/20 0.38
MAPT P10636 2/20 0.38
ATM Q13315 2/20 0.38
CYP3A4 P08684 1/20 0.38
TP53 P04637 1/20 0.38
TRPV4 Q9HBA0 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19639758 0.90 ALOX15 (0.44) ALOX15THRBHPGDCYP1A2CYP2C19
SCHEMBL19688313 0.78 ALOX15 (0.43) ALOX15THRBHPGDCYP1A2CYP2C19
SCHEMBL19639748 0.76 PTGDR2 (0.42) ALOX15THRBHPGDCYP1A2CYP2C19
SCHEMBL20322937 0.75 ALOX15 (0.51) ALOX15THRBHPGDCYP1A2CYP2C19
SCHEMBL9357893 0.72 LMNA (0.57) ALOX15THRBHPGDHTTALDH1A1
SCHEMBL5133571 0.70 HDAC1 (0.47) ALOX15HPGDCYP1A2CYP2C19HTT
SCHEMBL19639770 0.70 HDAC1 (0.45) ALOX15CYP1A2CYP2C19ALDH1A1HDAC1
SCHEMBL1423257 0.70 ALDH1A1 (0.55) THRBCYP1A2CYP2C19F2CYP2C9
SCHEMBL14954772 0.70 RAB9A (0.48) ALOX15HPGDCYP1A2CYP2C19HTT
SCHEMBL19639789 0.69 HDAC1 (0.47) ALOX15HPGDCYP1A2CYP2C19HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017207433-A9 HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF A DISEASE IN WHICH HNE IS IMPLICATED CHIESI FARMACEUTICI S.P.A. (IT) 2018-03-01 WO disclosed
WO-2017207433-A1 HETETOCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF A DISEASE IN WHICH HNE IS IMPLICATED CHIESI FARMACEUTICI S.P.A. (IT) 2017-12-07 WO disclosed