Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19639758 | 0.85 | ALOX15 (0.44) | ALOX15THRBHPGDHTTALDH1A1 | |
| SCHEMBL19688780 | 0.78 | ALOX15 (0.42) | ALOX15THRBHPGDHTTALDH1A1 | |
| SCHEMBL20322937 | 0.77 | ALOX15 (0.51) | ALOX15THRBHPGDHTTALDH1A1 | |
| SCHEMBL9357893 | 0.74 | LMNA (0.57) | ALOX15THRBHPGDHTTALDH1A1 | |
| SCHEMBL1423257 | 0.71 | ALDH1A1 (0.55) | THRBHTTALDH1A1GAAF2 | |
| SCHEMBL5845058 | 0.70 | ALOX15 (0.43) | ALOX15THRBHPGDHTTALDH1A1 | |
| SCHEMBL798803 | 0.70 | TSHR (0.54) | ALOX15THRBHPGDHTTALDH1A1 | |
| SCHEMBL28787504 | 0.70 | PRKCA (0.56) | THRBHPGDHTTALDH1A1MAPT | |
| SCHEMBL18700509 | 0.70 | LTB4R2 (0.48) | ALOX15THRBHPGDHTTALDH1A1 | |
| SCHEMBL333191 | 0.69 | SMN1; SMN2 (0.65) | HTTALDH1A1MAPTTP53GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017207433-A9 | HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF A DISEASE IN WHICH HNE IS IMPLICATED | CHIESI FARMACEUTICI S.P.A. (IT) | 2018-03-01 | — | — | WO | disclosed |
| WO-2017207433-A1 | HETETOCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF A DISEASE IN WHICH HNE IS IMPLICATED | CHIESI FARMACEUTICI S.P.A. (IT) | 2017-12-07 | — | — | WO | disclosed |