SCHEMBL19690460

SCHEMBL19690460

Nc1c(NC(=O)O)ccc(-n2cc3ccc(C(F)(F)F)cc3c2)c1F

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KCNQ2 O43526 5/20 0.39
▸ KCNQ3 O43525 4/20 0.39
▸ KIF11 P52732 1/20 0.38
▸ KCNQ4 P56696 2/20 0.37
▸ KCNQ5 Q9NR82 2/20 0.37
▸ MEN1 O00255 2/20 0.36
▸ KMT2A Q03164 2/20 0.36
▸ L3MBTL1 Q9Y468 1/20 0.36
▸ ALDH1A1 P00352 4/20 0.35
▸ PKM P14618 1/20 0.35
▸ KDM4E B2RXH2 1/20 0.35
▸ HPGD P15428 1/20 0.35
▸ HSD17B10 Q99714 1/20 0.35
▸ PIM1 P11309 1/20 0.34
▸ PIM2 Q9P1W9 1/20 0.34
▸ FPR1 P21462 1/20 0.34
▸ FPR2 P25090 1/20 0.34
▸ MAPT P10636 2/20 0.34
▸ TSHR P16473 1/20 0.34
▸ HTT P42858 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19690290 0.86 HDAC1 (0.36) KCNQ2KCNQ3MEN1KMT2AALDH1A1
SCHEMBL19690294 0.79 ALDH1A1 (0.39) KIF11MEN1KMT2AL3MBTL1ALDH1A1
SCHEMBL19695405 0.78 KIF11 (0.37) KIF11L3MBTL1ALDH1A1PKMKDM4E
SCHEMBL19690462 0.76 L3MBTL1 (0.40) KCNQ2KCNQ3KIF11KCNQ4KCNQ5
SCHEMBL19690590 0.73 NOTUM (0.41) KCNQ2MEN1KMT2AL3MBTL1ALDH1A1
SCHEMBL19690564 0.73 NOTUM (0.41) KCNQ2KCNQ3MEN1KMT2AL3MBTL1
SCHEMBL19358889 0.71 KIF11 (0.56) KIF11MEN1KMT2AALDH1A1KDM4E
SCHEMBL16060789 0.70 KDM4E (0.57) KIF11MEN1KMT2AL3MBTL1ALDH1A1
SCHEMBL21496315 0.69 KCNQ2 (0.54) KCNQ2KCNQ3KIF11KCNQ4KCNQ5
SCHEMBL17749067 0.68 KCNQ2 (0.75) KCNQ2KCNQ3KCNQ4KCNQ5KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11858900-B2 Fluorinated 2-amino-4-(substituted amino)phenyl carbamate derivatives OCUTERRA THERAPEUTICS, INC. (US) 2024-01-02 — — US disclosed
US-20210309612-A1 FLUORINATED 2-AMINO-4-(SUBSTITUTED AMINO)PHENYL CARBAMATE DERIVATIVES OCUTERRA THERAPEUTICS, INC. 2021-10-07 — — US disclosed
EP-3468947-A1 FLUORINATED 2-AMINO-4-(SUBSTITUTED AMINO)PHENYL CARBAMATE DERIVATIVES SciFluor Life Sciences, Inc. (US) 2019-04-17 — — EP disclosed
WO-2017214539-A1 FLUORINATED 2-AMINO-4-(SUBSTITUTED AMINO)PHENYL CARBAMATE DERIVATIVES SCIFLUOR LIFE SCIENCES, INC. (US) 2017-12-14 — — WO disclosed
US-20170355679-A1 FLUORINATED 2-AMINO-4-(SUBSTITUTED AMINO)PHENYL CARBAMATE DERIVATIVES SCIFLUOR LIFE SCIENCES, INC. 2017-12-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170355679-A1 FLUORINATED 2-AMINO-4-(SUBSTITUTED AMINO)PHENYL CARBAMATE DERIVATIVES KCNQ2, KCNQ1, KCNQ3 KCNQ2 1/4885KCNQ3 3/4885KIF11 894/4885
US-11858900-B2 Fluorinated 2-amino-4-(substituted amino)phenyl carbamate derivatives KCNQ2, KCNQ1, KCNQ3 KCNQ2 1/4885KCNQ3 3/4885KIF11 894/4885
US-20210309612-A1 FLUORINATED 2-AMINO-4-(SUBSTITUTED AMINO)PHENYL CARBAMATE DERIVATIVES KCNQ2, KCNQ1, KCNQ3 KCNQ2 1/4885KCNQ3 3/4885KIF11 894/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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