Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | ALPG | P10696 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | SUMO3 | P55854 | 1/20 | 0.41 |
| ▸ | SUMO2 | P61956 | 1/20 | 0.41 |
| ▸ | SUMO1 | P63165 | 1/20 | 0.41 |
| ▸ | RHOA | P61586 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 2/20 | 0.39 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10865574 | 0.76 | KMT2A (0.47) | KMT2AMEN1KDM4EMAPTRAB9A | |
| SCHEMBL19690955 | 0.75 | SETDB1 (0.54) | KMT2AMEN1KDM4EMAPTRAB9A | |
| SCHEMBL1850351 | 0.74 | KMT2A (0.45) | KMT2AMEN1KDM4EMAPTRAB9A | |
| SCHEMBL4105441 | 0.73 | RAB9A (0.42) | KMT2AMEN1KDM4EMAPTRAB9A | |
| SCHEMBL19691017 | 0.71 | SETDB1 (0.59) | KMT2AMEN1KDM4EMAPTRAB9A | |
| SCHEMBL896623 | 0.71 | KMT2A (0.59) | KMT2AMEN1KDM4EMAPTRAB9A | |
| SCHEMBL31497264 | 0.71 | KMT2A (0.59) | KMT2AMEN1KDM4EMAPTRAB9A | |
| SCHEMBL17629029 | 0.71 | MEN1 (0.53) | KMT2AMEN1KDM4EMAPTRAB9A | |
| SCHEMBL396525 | 0.70 | NCF1 (0.61) | KMT2AMEN1KDM4EMAPTRAB9A | |
| SCHEMBL29833517 | 0.70 | NCF1 (0.61) | KMT2AMEN1KDM4EMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9980954-B2 | Quinoline derivatives for inhibiting histone methyltransferases and use thereof | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2018-05-29 | — | — | US | claimed |
| US-20170354650-A1 | QUINOLINE DERIVATIVES FOR INHIBITING HISTONE METHYLTRANSFERASES AND USE THEREOF | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2017-12-14 | — | — | US | claimed |
| US-9980954-B2 | Quinoline derivatives for inhibiting histone methyltransferases and use thereof | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2018-05-29 | — | — | US | disclosed |
| US-20170354650-A1 | QUINOLINE DERIVATIVES FOR INHIBITING HISTONE METHYLTRANSFERASES AND USE THEREOF | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170354650-A1 | QUINOLINE DERIVATIVES FOR INHIBITING HISTONE METHYLTRANSFERASES AND USE THEREOF | NSD1, EHMT1, SETDB1 | KMT2A 17/4885MEN1 1806/4885KDM4E 50/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.