Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19703694 | 0.92 | NPC1 (0.62) | NPC1ALDH1A1HPGDLMNAKMT2A | |
| SCHEMBL19703777 | 0.87 | ALDH1A1 (0.46) | NPC1ALDH1A1HPGDLMNAKMT2A | |
| SCHEMBL19698164 | 0.85 | CYP2D6 (0.37) | NPC1ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL21664525 | 0.79 | POLB (0.55) | NPC1ALDH1A1LMNASMN1; SMN2RAB9A | |
| SCHEMBL17740037 | 0.78 | NPC1 (0.43) | NPC1ALDH1A1HPGDLMNAKMT2A | |
| SCHEMBL16330527 | 0.78 | ALDH1A1 (0.39) | ALDH1A1LMNA | |
| SCHEMBL19698112 | 0.78 | NPC1 (0.43) | NPC1ALDH1A1HPGDLMNAKMT2A | |
| SCHEMBL20034713 | 0.78 | NPC1 (0.43) | NPC1ALDH1A1HPGDLMNAKMT2A | |
| SCHEMBL43576 | 0.78 | PSMB8 (0.35) | HPGDLMNAKMT2ASMN1; SMN2 | |
| SCHEMBL12092238 | 0.77 | TACR1 (0.36) | ALDH1A1HPGDLMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170355731-A1 | AMATOXIN DERIVATIVES AND CONJUGATES THEREOF AS INHIBITORS OF RNA POLYMERASE | NOVARTIS INSTITUTE FOR FUNCTIONAL GENOMICS, INC., DBA GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170355731-A1 | AMATOXIN DERIVATIVES AND CONJUGATES THEREOF AS INHIBITORS OF RNA POLYMERASE | RNGTT, RNASE1, RNMT | NPC1 2704/4885ALDH1A1 3212/4885HPGD 3861/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.