Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.49 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 4/20 | 0.37 |
| ▸ | THRB | P10828 | 4/20 | 0.37 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.37 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.37 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.37 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | GUSB | P08236 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25493368 | 0.85 | MTNR1A (0.42) | CSNK2A1HAVCR2MTNR1AMTNR1BTHRA | |
| SCHEMBL22438748 | 0.77 | GRIN2D (0.44) | MTNR1AMTNR1BAXLHTR2A | |
| SCHEMBL19708398 | 0.77 | CSNK2A1 (0.53) | CSNK2A1HAVCR2PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL19838922 | 0.76 | GPR84 (0.51) | MTNR1AMTNR1BTHRATHRBPRKAB2 | |
| SCHEMBL31748373 | 0.73 | CSNK2A1 (0.53) | CSNK2A1HAVCR2PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL153945 | 0.73 | CSNK2A1 (0.53) | CSNK2A1HAVCR2PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL22438784 | 0.72 | THRA (0.42) | MTNR1AMTNR1BTHRATHRBPRKAB2 | |
| SCHEMBL3156224 | 0.71 | SRC (0.54) | CSNK2A1MTNR1AMTNR1BGPR84GUSB | |
| SCHEMBL12244358 | 0.71 | HTR2A (0.55) | GPR84GUSBHTR2AIDO1 | |
| SCHEMBL22156313 | 0.71 | GUSB (0.52) | GPR84GUSBGSK3BFFAR1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111448190-B | Substituted indole compounds | 百时美施贵宝公司 | 2023-09-26 | — | — | CN | disclosed |
| US-11739098-B2 | Substituted indole compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-08-29 | — | — | US | disclosed |
| US-11739098-B2 | Substituted indole compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-08-29 | — | — | US | disclosed |
| US-11739098-B2 | Substituted indole compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-08-29 | — | — | US | disclosed |
| EP-3710440-B1 | SUBSTITUTED INDOLE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2023-04-05 | — | — | EP | disclosed |
| US-20230098244-A1 | SUBSTITUTED INDOLE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2023-03-30 | — | — | US | disclosed |
| US-20210253593-A1 | SUBSTITUTED INDOLE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2021-08-19 | — | — | US | disclosed |
| US-20210253593-A1 | SUBSTITUTED INDOLE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2021-08-19 | — | — | US | disclosed |
| EP-3710440-A1 | SUBSTITUTED INDOLE COMPOUNDS | Bristol-Myers Squibb Company (US) | 2020-09-23 | — | — | EP | disclosed |
| CN-111448190-A | Substituted indole compounds | 百时美施贵宝公司 | 2020-07-24 | — | — | CN | disclosed |
| WO-2017212345-A2 | DETECTING MICROBIAL INFECTION IN WOUNDS | SYNOVO GMBH (DE) | 2017-12-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230098244-A1 | SUBSTITUTED INDOLE COMPOUNDS | TLR7, TLR1, HTR7 | CSNK2A1 2242/4885HAVCR2 684/4885MTNR1A 10/4885 |
| US-20210253593-A1 | SUBSTITUTED INDOLE COMPOUNDS | TLR7, TLR1, HTR7 | CSNK2A1 2242/4885HAVCR2 684/4885MTNR1A 10/4885 |
| US-11739098-B2 | Substituted indole compounds | TLR7, TLR1, HTR7 | CSNK2A1 2242/4885HAVCR2 684/4885MTNR1A 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.