Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 7/20 | 0.37 |
| ▸ | PRKCI | P41743 | 1/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.36 |
| ▸ | GABRE | P78334 | 1/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.36 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.36 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.36 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19743909 | 0.83 | NPSR1 (0.44) | ATRPRKCIMAPKAPK2GABRA1GABRG2 | |
| SCHEMBL30852147 | 0.83 | NPSR1 (0.44) | ATRPRKCIMAPKAPK2GABRA1GABRG2 | |
| SCHEMBL3868054 | 0.83 | GABRP (0.41) | ATRPRKCIMAPKAPK2GABRPGABRD | |
| Lithium Ion SCHEMBL19743870 | 0.77 | GRM5 (0.50) | ATRPRKCIMAPKAPK2GABRPGABRD | |
| Lithium Ion SCHEMBL19743961 | 0.75 | ATR (0.51) | ATRPRKDCGRM5 | |
| Lithium Ion SCHEMBL19743866 | 0.74 | ATR (0.33) | ATRPRKDCGRM5 | |
| SCHEMBL3979134 | 0.72 | GABRP (0.41) | PRKCIMAPKAPK2GABRPGABRDGABRA1 | |
| SCHEMBL30852257 | 0.72 | NPSR1 (0.42) | ATRPRKCIMAPKAPK2GABRA1GABRG2 | |
| SCHEMBL6405355 | 0.72 | MAPKAPK2 (0.41) | MAPKAPK2DHFR | |
| SCHEMBL13345759 | 0.70 | MAPKAPK2 (0.47) | MAPKAPK2GABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10759785-B2 | Compounds | Enterprise Therapeutics Limited (GB) | 2020-09-01 | — | — | US | disclosed |
| EP-3472154-B1 | COMPOUNDS | ENTERPRISE THERAPEUTICS LTD (GB) | 2020-08-12 | — | — | EP | disclosed |
| US-20190233402-A1 | COMPOUNDS | Enterprise Therapeutics Limited (GB) | 2019-08-01 | — | — | US | disclosed |
| EP-3472154-A1 | COMPOUNDS | Enterprise Therapeutics Limited (GB) | 2019-04-24 | — | — | EP | disclosed |
| WO-2017221008-A1 | COMPOUNDS | Enterprise Therapeutics Limited (GB) | 2017-12-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190233402-A1 | COMPOUNDS | CFTR, NHERF1, SCNN1A | ATR 3410/4885PRKCI 2738/4885MAPKAPK2 4238/4885 |
| US-10759785-B2 | Compounds | CFTR, NHERF1, SCNN1A | ATR 3410/4885PRKCI 2738/4885MAPKAPK2 4238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.