SCHEMBL197456

SCHEMBL197456

Clc1ccc(-c2ccc(Cl)cn2)nc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR1 P32246 1/20 0.46
CCR5 P51681 1/20 0.46
CCR8 P51685 1/20 0.46
HDAC6 Q9UBN7 1/20 0.46
GRM5 P41594 1/20 0.44
CNR2 P34972 1/20 0.44
ADRA2A P08913 2/20 0.43
ADRA2B P18089 2/20 0.43
ADRA2C P18825 2/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
PLAU P00749 1/20 0.43
CASP3 P42574 3/20 0.42
LMNA P02545 1/20 0.41
CYP2A6 P11509 1/20 0.41
PTK2 Q05397 1/20 0.40
P4HA1 P13674 1/20 0.39
P4HTM Q9NXG6 1/20 0.39
KDM1A O60341 1/20 0.38
MAOB P27338 1/20 0.38
TGFBR1 P36897 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31504098 1.00 CCR1 (0.46) CCR1CCR5CCR8HDAC6GRM5
SCHEMBL23348862 0.84 CASP3 (0.49) GRM5CNR2ADRA2AADRA2BADRA2C
SCHEMBL29577312 0.83 KDM4E (0.61) CCR1CCR5CCR8GRM5L3MBTL1
SCHEMBL197509 0.83 KDM4E (0.61) CCR1CCR5CCR8GRM5L3MBTL1
SCHEMBL21035528 0.82 KDM4E (0.39) CCR1CCR5CCR8HDAC6GRM5
SCHEMBL30528364 0.82 NPC1 (0.46) GRM5CNR2
SCHEMBL27970861 0.80 GRM5 (0.36) CCR1CCR5CCR8HDAC6GRM5
SCHEMBL30589693 0.80 METAP1 (0.44) HDAC6GRM5CNR2ADRA2AADRA2B
SCHEMBL1903499 0.80 LDHA (0.52) CNR2L3MBTL1KDM1AMAOB
SCHEMBL31646059 0.80 LDHA (0.52) CNR2L3MBTL1KDM1AMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230167144-A1 PREPARATION AND ITS APPLICATION OF A CYANIDE-BRIDGED METAL ORGANIC COMPOUND WITH INTRAMOLECULAR MAGNETIC TRANSFORMATION Hubei Jingmen Industrial Technology Research Institute Co., Ltd. (CN) 2023-06-01 US claimed
US-20230167144-A1 PREPARATION AND ITS APPLICATION OF A CYANIDE-BRIDGED METAL ORGANIC COMPOUND WITH INTRAMOLECULAR MAGNETIC TRANSFORMATION Hubei Jingmen Industrial Technology Research Institute Co., Ltd. (CN) 2023-06-01 US disclosed
US-11014886-B2 Method for preparing 2,2′-dipyridine and derivatives thereof NANJING REDSUN BIOCHEMISTRY CO., LTD. (CN) 2021-05-25 US disclosed
US-20200331857-A1 METHOD FOR PREPARING 2,2'-DIPYRIDINE AND DERIVATIVES THEREOF NANJING REDSUN BIOCHEMISTRY CO., LTD. (CN) 2020-10-22 US disclosed
CN-104423170-B Photosensitive polysiloxane composition, protective film and assembly with protective film 奇美实业股份有限公司 2019-05-24 CN disclosed
CN-109557764-A Chemically amplified positive photosensitive resin composition, resist pattern and method for forming the same, and electronic device 奇美实业股份有限公司 2019-04-02 CN disclosed
US-9673473-B2 Redox flow battery SAMSUNG ELECTRONICS CO., LTD. (KR) 2017-06-06 US disclosed
US-9389509-B2 Photosensitive polysiloxane composition, protecting film and element having the protecting film CHI MEI CORPORATION (TW) 2016-07-12 US disclosed
US-20150346601-A1 PHOTOSENSITIVE POLYSILOXANE COMPOSITION, PROTECTIVE FILM AND ELEMENT HAVING THE PROTECTIVE FILM CHI MEI CORPORATION (TW) 2015-12-03 US disclosed
US-20150234275-A1 PHOTOSENSITIVE POLYSILOXANE COMPOSITION, PROTECTING FILM AND ELEMENT HAVING THE PROTECTING FILM CHI MEI CORPORATION (TW) 2015-08-20 US disclosed
US-20030152960-A1 Methods for the electrochemical detection of multiple target compounds ROCHE MOLECULAR SYSTEMS, INC. 2003-08-14 US disclosed
EP-1006135-B1 Conjugated N-fluoropyridinium salt-containing polymer and use of the same DAIKIN IND LTD (JP) 2003-02-12 EP disclosed
WO-2002103753-A2 NANOELECTRONIC INTERCONNECTION AND ADDRESSING MYRICK JAMES J (US) 2002-12-27 WO disclosed
WO-2002042771-A2 DETECTION OF BINDING REACTIONS USING CATALYTIC ELECTROCHEMICAL LABELS UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2002-05-30 WO disclosed
US-20020037530-A1 Detection of binding reactions using labels detected by mediated catalytic electrochemistry STEWART DAVID H (US) 2002-03-28 US disclosed
US-6346387-B1 CONTACTING IMMOBILIZED BINDER WITH TEST SAMPLE TO COMPLEX TARGET; CONTACTING WITH SECOND BINDER HAVING EXOGENOUS OR ENDOGENOUS LABEL; OXIDATION WITH TRANSITION METAL COMPOUND; DETECTING OXIDATION-REDUCTION REACTION XANTHON, INC. 2002-02-12 US disclosed
EP-0787719-B1 CONJUGATED N-FLUOROPYRIDINIUM SALT POLYMER AND USE THEREOF DAIKIN IND LTD (JP) 2001-08-16 EP disclosed
EP-1006135-A1 Conjugated N-fluoropyridinium salt-containing polymer and use of the same DAIKIN INDUSTRIES, LIMITED (JP) 2000-06-07 EP disclosed
US-5736274-A ANODE ACTIVE MATERIAL AND SOLID ELECTROLYTE FOR BATTERIES; HIGH ELECTROMOTIVE FORCE; HIGH ENERGY DENSITY; POLLUTION CONTROL; FLUORINATING AGENTS; LOW INTERNAL RESISTANCE IN CHARGING AND DISCHARGING DAIKIN INDUSTRIES, LTD. (JP) 1998-04-07 US disclosed
EP-0787719-A1 CONJUGATED N-FLUOROPYRIDINIUM SALT POLYMER AND USE THEREOF DAIKIN INDUSTRIES, LTD. (JP) 1997-08-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200331857-A1 METHOD FOR PREPARING 2,2'-DIPYRIDINE AND DERIVATIVES THEREOF HRH2, AMPD2, QDPR CCR1 2897/4885CCR5 1807/4885CCR8 4285/4885
US-11014886-B2 Method for preparing 2,2′-dipyridine and derivatives thereof HRH2, AMPD2, DPYD CCR1 2915/4885CCR5 1791/4885CCR8 4291/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.