Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Dimethylspingosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 4/20 | 0.86 |
| ▸ | SPHK1 | Q9NYA1 | 4/20 | 0.86 |
| ▸ | CETP | P11597 | 4/20 | 0.86 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.54 |
| ▸ | THRB | P10828 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | GMNN | O75496 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | GLA | P06280 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | CXCR5 | P32302 | 2/20 | 0.54 |
| ▸ | CCR6 | P51684 | 2/20 | 0.54 |
| ▸ | BLM | P54132 | 2/20 | 0.54 |
| ▸ | UBE2N | P61088 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylspingosine SCHEMBL121926 | 0.93 | SPHK2 (1.00) | SPHK2SPHK1CETPPLA2G4AMAPT | |
| Dimethylspingosine SCHEMBL121927 | 0.93 | SPHK2 (1.00) | SPHK2SPHK1CETPPLA2G4AMAPT | |
| Dimethylspingosine SCHEMBL8258015 | 0.93 | SPHK2 (1.00) | SPHK2SPHK1CETPPLA2G4AMAPT | |
| Dimethylspingosine SCHEMBL5493697 | 0.93 | SPHK2 (1.00) | SPHK2SPHK1CETPPLA2G4AMAPT | |
| SCHEMBL22911020 | 0.82 | PLA2G4A (0.73) | SPHK2SPHK1CETPPLA2G4AALDH1A1 | |
| SCHEMBL3768316 | 0.82 | PLA2G4A (0.73) | SPHK2SPHK1CETPPLA2G4AALDH1A1 | |
| Sphingosine SCHEMBL4779279 | 0.79 | SPHK2 (0.85) | SPHK2SPHK1CETPMAPTMEN1 | |
| Sphingosine SCHEMBL21439824 | 0.79 | SPHK2 (0.85) | SPHK2SPHK1CETPMAPTMEN1 | |
| Sphingosine SCHEMBL320150 | 0.79 | SPHK2 (0.85) | SPHK2SPHK1CETPMAPTMEN1 | |
| Sphingosine SCHEMBL19137 | 0.79 | SPHK2 (0.85) | SPHK2SPHK1CETPMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017223152-A1 | ENHANCING DNA REPAIR AND PREVENTING AGING AND ITS CONSEQUENCES IN REPRODUCTIVE AND OTHER CELLS | NEW YORK MEDICAL COLLEGE (US) | 2017-12-28 | — | — | WO | disclosed |