Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.44 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9334108 | 0.74 | TSHR (0.31) | TSHR | |
| SCHEMBL15390053 | 0.73 | LMNA (0.50) | ALDH1A1L3MBTL1LMNATSHRGAA | |
| SCHEMBL19746967 | 0.73 | L3MBTL1 (0.39) | ALDH1A1SMN1; SMN2MAPTL3MBTL1LMNA | |
| SCHEMBL19744921 | 0.73 | SMN1; SMN2 (0.41) | ALDH1A1SMN1; SMN2MAPTHSD17B10L3MBTL1 | |
| SCHEMBL8995181 | 0.68 | — | — | |
| SCHEMBL9493940 | 0.67 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2MAPTHSD17B10L3MBTL1 | |
| SCHEMBL4302 | 0.67 | POLB (0.44) | ALDH1A1SMN1; SMN2HSD17B10L3MBTL1RAB9A | |
| SCHEMBL192919 | 0.66 | — | — | |
| SCHEMBL2658516 | 0.65 | BRD4 (0.55) | ALDH1A1HSD17B10L3MBTL1KMT2AGAA | |
| SCHEMBL29052332 | 0.65 | LMNA (0.69) | ALDH1A1SMN1; SMN2MAPTHSD17B10L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3471729-A1 | THERAPEUTIC COMPOUNDS | Rutgers, the State University of New Jersey (US) | 2019-04-24 | — | — | EP | claimed |
| WO-2017222930-A1 | THERAPEUTIC COMPOUNDS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2017-12-28 | — | — | WO | claimed |