SCHEMBL19756271

SCHEMBL19756271

CC(C)(C)CC(=O)NC(CC(=O)C(C)(C)C)C(=O)NCCN

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRIA1 P42261 5/20 0.35
TACR1 P25103 1/20 0.33
TACR3 P29371 1/20 0.33
CHRNB2 P17787 4/20 0.33
CHRNB4 P30926 4/20 0.33
CHRNA3 P32297 4/20 0.33
CHRNA4 P43681 4/20 0.33
GRIN1 Q05586 2/20 0.33
GRIN2A Q12879 2/20 0.33
GRM1 Q13255 2/20 0.33
NMT2 O60551 1/20 0.33
NMT1 P30419 1/20 0.33
ECE1 P42892 1/20 0.33
CHRNA1 P02708 1/20 0.32
CHRNG P07510 1/20 0.32
CHRNB1 P11230 1/20 0.32
CHRND Q07001 1/20 0.32
CCKBR P32239 1/20 0.32
SIRT6 Q8N6T7 1/20 0.32
SIRT1 Q96EB6 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20623016 0.86 TACR1 (0.33) TACR1TACR3ECE1CCKBR
SCHEMBL19756282 0.84 GRIA1 (0.44) GRIA1TACR1TACR3SIRT6SIRT1
SCHEMBL19756279 0.83 KDM4E (0.34) ECE1CCKBR
SCHEMBL21536833 0.80 GRIA1 (0.37) GRIA1TACR1TACR3SIRT6SIRT1
SCHEMBL18477469 0.77 HPGD (0.35)
SCHEMBL24823972 0.75 TACR1 (0.32) TACR1TACR3
SCHEMBL21285412 0.73 KDM4E (0.33)
SCHEMBL19756283 0.72
SCHEMBL19756277 0.72 DPP7 (0.36) TACR1TACR3ECE1
SCHEMBL1963990 0.72 HPGD (0.42)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11564974-B2 Combination therapy with controlled-release CNP agonists ASCENDIS PHARMA GROWTH DISORDERS A/S (DK) 2023-01-31 US disclosed
US-20220409700-A1 CONTROLLED-RELEASE CNP AGONISTS WITH REDUCED SIDE-EFFECTS ASCENDIS PHARMA GROWTH DISORDERS AS (DK) 2022-12-29 US disclosed
US-20220211817-A1 CONTROLLED-RELEASE CNP AGONISTS WITH LOW NPR-C BINDING ASCENDIS PHARMA GROWTH DISORDERS AS (DK) 2022-07-07 US disclosed
US-11311604-B2 Controlled-release CNP agonists with low NPR-C binding ASCENDIS PHARMA GROWTH DISORDERS A/S (DK) 2022-04-26 US disclosed
US-11154593-B2 CNP prodrugs with large carrier moieties ASCENDIS PHARMA GROWTH DISORDERS A/S (DK) 2021-10-26 US disclosed
US-20210177942-A1 CNP PRODRUGS WITH LARGE CARRIER MOIETIES ASCENDIS PHARMA GROWTH DISORDERS A/S (DK) 2021-06-17 US disclosed
US-20210077584-A1 CNP PRODRUGS WITH LARGE CARRIER MOIETIES ASCENDIS PHARMA GROWTH DISORDERS AS (DK) 2021-03-18 US disclosed
US-20210069339-A1 CNP PRODRUGS ASCENDIS PHARMA GROWTH DISORDERS A/S (DK) 2021-03-11 US disclosed
US-10835578-B2 CNP prodrugs with large carrier moieties ASCENDIS PHARMA GROWTH DISORDERS A/S (DK) 2020-11-17 US disclosed
US-20200276270-A1 Combination Therapy with Controlled-Release CNP Agonists ASCENDIS PHARMA GROWTH DISORDERS A/S (DK) 2020-09-03 US disclosed
US-20190328840-A1 CONTROLLED-RELEASE CNP AGONISTS WITH LOW INITIAL NPR-B ACTIVITY ASCENDIS PHARMA GROWTH DISORDERS A/S (DK) 2019-10-31 US disclosed
US-20190328841-A1 CONTROLLED-RELEASE CNP AGONISTS WITH REDUCED SIDE-EFFECTS ASCENDIS PHARMA GROWTH DISORDERS A/S (DK) 2019-10-31 US disclosed
US-20190255183-A1 CNP PRODRUGS ASCENDIS PHARMA GROWTH DISORDERS A/S (DK) 2019-08-22 US disclosed
US-20190015481-A1 CNP PRODRUGS WITH LARGE CARRIER MOIETIES ASCENDIS PHARMA GROWTH DISORDERS A/S (DK) 2019-01-17 US disclosed
US-20190000926-A1 CONTROLLED-RELEASE CNP AGONISTS WITH LOW NPR-C BINDING ASCENDIS PHARMA GROWTH DISORDERS A/S (DK) 2019-01-03 US disclosed
US-20170368189-A1 CNP PRODRUGS ASCENDIS PHARMA GROWTH DISORDERS A/S (DK) 2017-12-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (16 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220409700-A1 CONTROLLED-RELEASE CNP AGONISTS WITH REDUCED SIDE-EFFECTS CNP, NPR1, NTSR2 GRIA1 639/4885TACR1 99/4885TACR3 151/4885
US-11154593-B2 CNP prodrugs with large carrier moieties CNP, LNPEP, CSGALNACT1 GRIA1 3132/4885TACR1 362/4885TACR3 1017/4885
US-20210069339-A1 CNP PRODRUGS NPPA, NPR1, NPR3 GRIA1 3408/4885TACR1 64/4885TACR3 166/4885
US-20190255183-A1 CNP PRODRUGS NPPA, NPR1, NPR3 GRIA1 3408/4885TACR1 64/4885TACR3 166/4885
US-20190328840-A1 CONTROLLED-RELEASE CNP AGONISTS WITH LOW INITIAL NPR-B ACTIVITY NPR1, NPR3, CNP GRIA1 723/4885TACR1 131/4885TACR3 81/4885
US-20200276270-A1 Combination Therapy with Controlled-Release CNP Agonists CNP, NPR1, NGF GRIA1 778/4885TACR1 137/4885TACR3 310/4885
US-20190000926-A1 CONTROLLED-RELEASE CNP AGONISTS WITH LOW NPR-C BINDING NPR1, NPR3, NPSR1 GRIA1 567/4885TACR1 24/4885TACR3 53/4885
US-20210077584-A1 CNP PRODRUGS WITH LARGE CARRIER MOIETIES CNP, LNPEP, CSGALNACT1 GRIA1 3132/4885TACR1 362/4885TACR3 1017/4885
US-20220211817-A1 CONTROLLED-RELEASE CNP AGONISTS WITH LOW NPR-C BINDING NPR1, NPR3, NPSR1 GRIA1 567/4885TACR1 24/4885TACR3 53/4885
US-11311604-B2 Controlled-release CNP agonists with low NPR-C binding NPR1, NPR3, NPSR1 GRIA1 567/4885TACR1 24/4885TACR3 53/4885
US-20190328841-A1 CONTROLLED-RELEASE CNP AGONISTS WITH REDUCED SIDE-EFFECTS CNP, NPR1, NTSR2 GRIA1 639/4885TACR1 99/4885TACR3 151/4885
US-20210177942-A1 CNP PRODRUGS WITH LARGE CARRIER MOIETIES CNP, LNPEP, CSGALNACT1 GRIA1 3132/4885TACR1 362/4885TACR3 1017/4885
US-11564974-B2 Combination therapy with controlled-release CNP agonists CNP, NPR1, NGF GRIA1 778/4885TACR1 137/4885TACR3 310/4885
US-10835578-B2 CNP prodrugs with large carrier moieties CNP, LNPEP, CSGALNACT1 GRIA1 3132/4885TACR1 362/4885TACR3 1017/4885
US-20190015481-A1 CNP PRODRUGS WITH LARGE CARRIER MOIETIES CNP, LNPEP, CSGALNACT1 GRIA1 3132/4885TACR1 362/4885TACR3 1017/4885
US-20170368189-A1 CNP PRODRUGS NPPA, NPR1, NPR3 GRIA1 3408/4885TACR1 64/4885TACR3 166/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.