Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 11/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.49 |
| ▸ | CDC42BPA | Q5VT25 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | FPR1 | P21462 | 2/20 | 0.44 |
| ▸ | FPR2 | P25090 | 2/20 | 0.44 |
| ▸ | FPR3 | P25089 | 1/20 | 0.44 |
| ▸ | TSPO | P30536 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17912910 | 0.87 | ROCK2 (0.51) | ROCK2ROCK1CYP2C9CDC42BPACYP3A4 | |
| SCHEMBL20511561 | 0.82 | ROCK2 (0.69) | ROCK2ROCK1CYP2C9CDC42BPACYP3A4 | |
| SCHEMBL3116059 | 0.80 | ROCK2 (0.67) | ROCK2ROCK1CYP2C9CDC42BPACYP3A4 | |
| SCHEMBL19661646 | 0.79 | POLB (0.55) | ROCK2ROCK1CYP2C9CDC42BPACYP3A4 | |
| SCHEMBL17913011 | 0.74 | SMN1; SMN2 (0.43) | ROCK2ROCK1CYP2C9POLBSMN1; SMN2 | |
| SCHEMBL29804160 | 0.73 | ROCK2 (0.66) | ROCK2ROCK1CYP2C9CDC42BPACYP3A4 | |
| SCHEMBL28587953 | 0.73 | ROCK2 (0.66) | ROCK2ROCK1CYP2C9CDC42BPACYP3A4 | |
| SCHEMBL21688857 | 0.72 | ROCK2 (0.70) | ROCK2ROCK1CYP2C9CDC42BPACYP3A4 | |
| SCHEMBL29804304 | 0.72 | ROCK2 (0.67) | ROCK2ROCK1CYP2C9CDC42BPACYP3A4 | |
| SCHEMBL28595202 | 0.72 | ROCK2 (0.67) | ROCK2ROCK1CYP2C9CDC42BPACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180000788-A1 | CYCLIC UREAS AS INHIBITORS OF ROCK | BRISTOL MYERS SQUIBB CO (US) | 2018-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180000788-A1 | CYCLIC UREAS AS INHIBITORS OF ROCK | MYLK, ROCK1, UACA | ROCK2 4/4885ROCK1 2/4885CYP2C9 2598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.