Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 9/20 | 0.67 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.67 |
| ▸ | CDC42BPA | Q5VT25 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | FPR1 | P21462 | 1/20 | 0.49 |
| ▸ | FPR3 | P25089 | 1/20 | 0.49 |
| ▸ | FPR2 | P25090 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19661646 | 0.87 | POLB (0.55) | ROCK2ROCK1CYP2C9CDC42BPASMN1; SMN2 | |
| SCHEMBL20511561 | 0.84 | ROCK2 (0.69) | ROCK2ROCK1CYP2C9CDC42BPASMN1; SMN2 | |
| SCHEMBL12688033 | 0.81 | HSD17B2 (0.75) | POLBHSD17B2MEN1KMT2A | |
| SCHEMBL3119081 | 0.81 | BAZ1A (0.64) | ROCK2ROCK1CYP2C9CDC42BPASMN1; SMN2 | |
| SCHEMBL3253046 | 0.80 | ROCK2 (1.00) | ROCK2ROCK1CYP2C9CDC42BPACYP3A4 | |
| SCHEMBL19759552 | 0.80 | ROCK2 (0.53) | ROCK2ROCK1CYP2C9CDC42BPASMN1; SMN2 | |
| SCHEMBL29140953 | 0.79 | MTOR (0.65) | ROCK2ROCK1CYP2C9CDC42BPASMN1; SMN2 | |
| SCHEMBL17912910 | 0.77 | ROCK2 (0.51) | ROCK2ROCK1CYP2C9CDC42BPASMN1; SMN2 | |
| SCHEMBL6417242 | 0.76 | HSD17B2 (0.63) | ROCK2ROCK1CYP2C9CDC42BPASMN1; SMN2 | |
| SCHEMBL29804304 | 0.75 | ROCK2 (0.67) | ROCK2ROCK1CYP2C9CDC42BPASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | disclosed |