Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | ACP3 | P15309 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16798426 | 0.77 | IDO1 (0.39) | ALDH1A1IDO1TDO2 | |
| SCHEMBL28832809 | 0.77 | POLB (0.33) | DPP4TSHRF2ALDH1A1ACP3 | |
| SCHEMBL7623731 | 0.74 | TSHR (0.43) | DPP4TSHRF2ALDH1A1HTR2A | |
| SCHEMBL596278 | 0.74 | RIPK1 (0.40) | DPP4TSHRF2HTR2ATAAR1 | |
| SCHEMBL16960501 | 0.73 | ACP3 (0.40) | TSHRALDH1A1ACP3 | |
| SCHEMBL536997 | 0.72 | DPP4 (0.41) | DPP4TSHRF2ALDH1A1HTR2A | |
| SCHEMBL10069117 | 0.72 | ESR1 (0.59) | DPP4TSHRF2ALDH1A1HTR2A | |
| SCHEMBL6835370 | 0.70 | DPP4 (0.39) | DPP4TSHRF2ALDH1A1HTR2A | |
| SCHEMBL7772037 | 0.70 | DPP4 (0.39) | DPP4TSHRF2ALDH1A1HTR2A | |
| SCHEMBL5610559 | 0.70 | PARP1 (0.36) | HTR2ATAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 132 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10071984-B2 | Histone demethylase inhibitors | CELGENE QUANTICEL RESEARCH, INC. (US) | 2018-09-11 | — | — | US | claimed |
| US-9676770-B2 | Histone demethylase inhibitors | CELGENE QUANTICEL RESEARCH, INC. (US) | 2017-06-13 | — | — | US | claimed |
| CN-103232324-B | The preparation method of a kind of (R)-3,5-pairs of (trifluoromethyl) phenylethyl alcohols | GUANGXI XINJING SCI. & TECH. CO., LTD. (CN) | 2016-03-16 | — | — | CN | claimed |
| CN-105330517-A | Method for synthesizing 3,5-bis(trifluoromethyl) phenethyl alcohol | ENANTIOTECH CORP LTD | 2016-02-17 | — | — | CN | claimed |
| CN-103382208-A | Preparation method of Arglabin | ACCENDATECH CO LTD | 2013-11-06 | — | — | CN | claimed |
| CN-103232324-A | Method for preparing (R)-3,5-bis(trifluoromethyl)benzene-ethanol | GUANGXI XINJING TECHNOLOGY CO LTD | 2013-08-07 | — | — | CN | claimed |
| US-8344018-B2 | Oxindolyl inhibitor compounds | GILEAD SCIENCES, INC. (US) | 2013-01-01 | — | — | US | claimed |
| US-8134000-B2 | Imidazolyl pyrimidine inhibitor compounds | GILEAD SCIENCES, INC. (US) | 2012-03-13 | — | — | US | claimed |
| US-8124764-B2 | Fused heterocyclyc inhibitor compounds | GILEAD SCIENCES, INC. (US) | 2012-02-28 | — | — | US | claimed |
| JP-2011528040-A | — | — | 2011-11-10 | — | — | JP | claimed |
| US-20100009990-A1 | IMIDAZOLYL PYRIMIDINE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. | 2010-01-14 | — | — | US | claimed |
| EP-2061449-A1 | SUBSTITUTED ACETYLENIC COMPOUNDS USEFUL FOR THE TREATMENT OF DISEASES | Leo Pharma A/S (DK) | 2009-05-27 | — | — | EP | claimed |
| US-20090005374-A1 | IMIDAZOPYRIDINYL THIAZOLYL HISTONE DEACETYLASE INHIBITORS | GILEAD SCIENCES, INC. | 2009-01-01 | — | — | US | claimed |
| WO-2009002534-A1 | IMIDAZOPYRIDINYL THIAZOLYL HISTONE DEACETYLASE INHIBITORS | GILEAD COLORADO, INC. (US) | 2008-12-31 | — | — | WO | claimed |
| WO-2008019690-A1 | SUBSTITUTED ACETYLENIC COMPOUNDS USEFUL FOR THE TREATMENT OF DISEASES | LEO PHARMA A/S (DK) | 2008-02-21 | — | — | WO | claimed |
| EP-1670446-A2 | METHOD OF INHIBITING REMNANT LIPOPROTEIN PRODUCTION | JAPAN TOBACCO INC. (JP) | 2006-06-21 | — | — | EP | claimed |
| WO-2005030185-A2 | METHOD OF INHIBITING REMNANT LIPOPROTEIN PRODUCTION | JAPAN TOBACCO INC. (JP) | 2005-04-07 | — | — | WO | claimed |
| US-5389612-A | Treating infections caused by clostridium histolyticum and pseudomonas aeruginosa; enzyme inhibitors | COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) | 1995-02-14 | — | — | US | claimed |
| US-4166827-A | DENTAL PLAQUE | COOPER LABORATORIES, INC. (US) | 1979-09-04 | — | — | US | claimed |
| US-4110328-A | Bis-carbamylguanidinoazaalkane antimicrobial compounds | COOPER LABORATORIES, INC. (US) | 1978-08-29 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10071984-B2 | Histone demethylase inhibitors | KDM1B, KDM1A, KDM3B | DPP4 855/4885TSHR 3927/4885F2 4865/4885 |
| US-20100009990-A1 | IMIDAZOLYL PYRIMIDINE INHIBITOR COMPOUNDS | HDAC1, CDK9, CDK2 | DPP4 1727/4885TSHR 3511/4885F2 3441/4885 |
| US-20090005374-A1 | IMIDAZOPYRIDINYL THIAZOLYL HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC8, HDAC5 | DPP4 993/4885TSHR 3211/4885F2 4533/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.