Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 14/20 | 0.74 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.60 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1817784 | 0.91 | ADAMTS5 (0.80) | ADAMTS5ADAMTS4HSP90AA1RAB9AKDM4E | |
| SCHEMBL1817388 | 0.85 | ADAMTS5 (1.00) | ADAMTS5ADAMTS4 | |
| SCHEMBL1813127 | 0.80 | ADAMTS5 (1.00) | ADAMTS5ADAMTS4HSP90AA1RAB9AKDM4E | |
| SCHEMBL1814054 | 0.79 | ADAMTS5 (1.00) | ADAMTS5HSP90AA1RAB9AKDM4EALOX12 | |
| SCHEMBL24634687 | 0.78 | RAB9A (0.60) | ADAMTS5HSP90AA1KMT2ARAB9AMEN1 | |
| SCHEMBL29855994 | 0.78 | RAB9A (0.60) | ADAMTS5HSP90AA1KMT2ARAB9AMEN1 | |
| SCHEMBL1814188 | 0.77 | ADAMTS5 (1.00) | ADAMTS5HSP90AA1RAB9AKDM4EL3MBTL1 | |
| SCHEMBL1814022 | 0.75 | ADAMTS5 (1.00) | ADAMTS5ADAMTS4 | |
| SCHEMBL28783396 | 0.75 | ADAMTS5 (0.83) | ADAMTS5HSP90AA1RAB9AKDM4EL3MBTL1 | |
| SCHEMBL1814553 | 0.75 | ADAMTS5 (1.00) | ADAMTS5ADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180009903-A1 | MODULATING ADIPOSE TISSUE AND ADIPOGENESIS | KATHOLIEKE UNIV LEUVEN KU LEUVEN RESEARCH & DEVELOPMENT (BE) | 2018-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180009903-A1 | MODULATING ADIPOSE TISSUE AND ADIPOGENESIS | ADAMTS5, ADAMTS1, ADAMTS7 | ADAMTS5 1/4885ADAMTS4 4/4885HSP90AA1 647/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.