Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSTK1 | Q9Y2Q3 | 2/20 | 0.65 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.65 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 5/20 | 0.38 |
| ▸ | ACE | P12821 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ECE1 | P42892 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | FNTA | P49354 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18383664 | 1.00 | GSTK1 (0.65) | GSTK1PTGS1GLO1ALDH1A1MAPT | |
| SCHEMBL24829528 | 1.00 | GSTK1 (0.65) | GSTK1PTGS1GLO1ALDH1A1MAPT | |
| SCHEMBL26819626 | 0.91 | PTGS1 (0.62) | GSTK1PTGS1GLO1ALDH1A1MAPT | |
| SCHEMBL26483467 | 0.89 | PTGS1 (0.60) | GSTK1PTGS1GLO1ALDH1A1MAPT | |
| SCHEMBL18924223 | 0.88 | PTGS1 (0.52) | GSTK1PTGS1GLO1ALDH1A1MAPT | |
| SCHEMBL14781467 | 0.88 | PTGS1 (0.66) | GSTK1PTGS1GLO1ALDH1A1MAPT | |
| SCHEMBL25861459 | 0.87 | PTGS1 (0.58) | GSTK1PTGS1GLO1ALDH1A1MAPT | |
| SCHEMBL18924221 | 0.86 | PTGS1 (0.50) | GSTK1PTGS1GLO1ALDH1A1MAPT | |
| SCHEMBL19940239 | 0.84 | PTGS1 (0.47) | GSTK1PTGS1GLO1ALDH1A1MAPT | |
| SCHEMBL25861362 | 0.83 | PTGS1 (0.48) | GSTK1PTGS1GLO1FOLH1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2928876-B1 | NUCLEOSIDE KINASE BYPASS COMPOSITIONS AND METHODS | MERCK SHARP & DOHME (US) | 2018-01-17 | — | — | EP | disclosed |