⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20621309 | 0.88 | — | — | |
| SCHEMBL19779245 | 0.80 | NOS3 (0.31) | — | |
| SCHEMBL20621277 | 0.76 | NOS2 (0.33) | — | |
| SCHEMBL24574394 | 0.73 | USP2 (0.30) | — | |
| SCHEMBL19779999 | 0.73 | ALDH1A1 (0.34) | — | |
| SCHEMBL22096909 | 0.70 | NOS2 (0.36) | — | |
| SCHEMBL25887311 | 0.70 | HTR2A (0.36) | — | |
| SCHEMBL21883622 | 0.69 | NOS2 (0.43) | — | |
| SCHEMBL19880512 | 0.69 | — | — | |
| SCHEMBL21884029 | 0.68 | NOS2 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210171492-A1 | SOMATOSTATIN MODULATORS AND USES THEREOF | Crinetics Pharmaceuticals, Inc. | 2021-06-10 | — | — | US | disclosed |
| US-10597377-B2 | Somatostatin modulators and uses thereof | Crinetics Pharmaceuticals, Inc. (US) | 2020-03-24 | — | — | US | disclosed |
| US-20180016252-A1 | SOMATOSTATIN MODULATORS AND USES THEREOF | Crinetics Pharmaceuticals, Inc. | 2018-01-18 | — | — | US | disclosed |