Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20621309 | 0.85 | — | — | |
| SCHEMBL20621313 | 0.84 | NOS3 (0.31) | NOS3NOS2 | |
| SCHEMBL19880512 | 0.81 | — | — | |
| SCHEMBL20621302 | 0.79 | ADRA2A (0.33) | — | |
| SCHEMBL18978721 | 0.79 | USP2 (0.37) | USP2ALDH1A1GAAPKMHPGD | |
| SCHEMBL18978703 | 0.79 | USP2 (0.37) | USP2ALDH1A1GAAPKMHPGD | |
| SCHEMBL20621321 | 0.77 | NOS2 (0.48) | USP2ALDH1A1GAAPKMHPGD | |
| SCHEMBL23046372 | 0.76 | TSHR (0.32) | USP2ALDH1A1GAAPKMHPGD | |
| SCHEMBL31043414 | 0.73 | — | — | |
| SCHEMBL20621434 | 0.73 | L3MBTL1 (0.38) | ALDH1A1GAANOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4265610-A1 | MACROCYCLIC K-RAS G12C INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2023-10-25 | — | — | EP | disclosed |
| WO-2022134773-A1 | MACROCYCLIC K-RAS G12C INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海和誉生物医药科技有限公司 | 2022-06-30 | — | — | WO | disclosed |