⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20621302 | 0.83 | ADRA2A (0.33) | — | |
| SCHEMBL24574394 | 0.81 | USP2 (0.30) | — | |
| SCHEMBL20621309 | 0.80 | — | — | |
| SCHEMBL18978721 | 0.74 | USP2 (0.37) | — | |
| SCHEMBL18978703 | 0.74 | USP2 (0.37) | — | |
| SCHEMBL20621321 | 0.73 | NOS2 (0.48) | — | |
| SCHEMBL23046372 | 0.71 | TSHR (0.32) | — | |
| SCHEMBL20621434 | 0.69 | L3MBTL1 (0.38) | — | |
| SCHEMBL21173560 | 0.69 | ALDH1A1 (0.33) | — | |
| SCHEMBL19780270 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10597377-B2 | Somatostatin modulators and uses thereof | Crinetics Pharmaceuticals, Inc. (US) | 2020-03-24 | — | — | US | disclosed |
| US-9896432-B2 | Somatostatin modulators and uses thereof | Crinetics Pharmaceuticals, Inc. (US) | 2018-02-20 | — | — | US | disclosed |