Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19782115 | 0.81 | KDM4E (0.34) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL38655175 | 0.79 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNAMEN1KMT2AKDM4E | |
| SCHEMBL19781866 | 0.76 | SMN1; SMN2 (0.45) | SMN1; SMN2LMNAMEN1KMT2AKDM4E | |
| SCHEMBL30760421 | 0.76 | MAPT (0.48) | SMN1; SMN2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL31716064 | 0.76 | SMN1; SMN2 (0.45) | SMN1; SMN2LMNAMEN1KMT2AKDM4E | |
| SCHEMBL23214039 | 0.76 | MAPT (0.48) | SMN1; SMN2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL24614557 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL17765273 | 0.73 | SMN1; SMN2 (0.42) | SMN1; SMN2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL5740030 | 0.72 | MAPT (0.47) | SMN1; SMN2LMNAMEN1KMT2AKDM4E | |
| SCHEMBL16430586 | 0.72 | CHRNB2 (0.39) | SMN1; SMN2LMNAMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190152962-A1 | CYCLOPROPYL DERIVATIVES AS ROR-GAMMA MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2019-05-23 | — | — | US | disclosed |
| WO-2018011746-A1 | CYCLOPROPYL DERIVATIVES AS ROR-GAMMA MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2018-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190152962-A1 | CYCLOPROPYL DERIVATIVES AS ROR-GAMMA MODULATORS | RORC, RORB, RORA | SMN1; SMN2 3885/4885LMNA 3727/4885MEN1 4599/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.