Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CXCR2 | P25025 | 4/20 | 0.40 |
| ▸ | CXCR1 | P25024 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4432631 | 0.86 | ALDH1A1 (0.65) | NPC1POLBRAB9ATDP1HPGD | |
| SCHEMBL2715327 | 0.81 | ALDH1A1 (0.42) | HPGDALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL9075726 | 0.81 | HPGD (0.68) | RAB9AHPGDALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL30003977 | 0.80 | KDM4E (0.47) | NPC1RAB9AHPGDALDH1A1CYP1A2 | |
| SCHEMBL24724107 | 0.80 | KDM4E (0.47) | NPC1RAB9AHPGDALDH1A1CYP1A2 | |
| SCHEMBL30003144 | 0.79 | HPGD (0.50) | NPC1RAB9AHPGDALDH1A1CYP1A2 | |
| SCHEMBL1091823 | 0.79 | HPGD (0.50) | NPC1RAB9AHPGDALDH1A1CYP1A2 | |
| SCHEMBL27385633 | 0.78 | HPGD (0.48) | NPC1RAB9AHPGDALDH1A1CYP1A2 | |
| SCHEMBL1716325 | 0.78 | NPC1 (0.48) | NPC1POLBRAB9ATDP1HPGD | |
| SCHEMBL21313793 | 0.77 | NPC1 (0.47) | NPC1POLBRAB9ATDP1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190152962-A1 | CYCLOPROPYL DERIVATIVES AS ROR-GAMMA MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2019-05-23 | — | — | US | disclosed |
| US-20190152962-A1 | CYCLOPROPYL DERIVATIVES AS ROR-GAMMA MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2019-05-23 | — | — | US | disclosed |
| WO-2018011746-A1 | CYCLOPROPYL DERIVATIVES AS ROR-GAMMA MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2018-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190152962-A1 | CYCLOPROPYL DERIVATIVES AS ROR-GAMMA MODULATORS | RORC, RORB, RORA | NPC1 645/4885POLB 3719/4885RAB9A 1396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.