Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
| ▸ | ADAMTS13 | Q76LX8 | 1/20 | 0.35 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19782983 | 0.78 | MAPT (0.45) | MAPTLMNAMAPK1PARP1L3MBTL1 | |
| SCHEMBL19783019 | 0.77 | ALDH1A1 (0.42) | MAPTLMNAMAPK1PARP1L3MBTL1 | |
| SCHEMBL19782727 | 0.77 | GSTO1 (0.37) | MAPTLMNAROCK2GSTO1L3MBTL1 | |
| SCHEMBL19783002 | 0.76 | LMNA (0.36) | MAPTLMNAPARP1GSTO1ADAMTS4 | |
| SCHEMBL19783021 | 0.69 | ALDH1A1 (0.49) | MAPTLMNAMAPK1L3MBTL1ALDH1A1 | |
| SCHEMBL19783107 | 0.67 | ALDH1A1 (0.47) | MAPTLMNAMAPK1L3MBTL1ALDH1A1 | |
| SCHEMBL15993205 | 0.65 | ALDH1A1 (0.41) | MAPTLMNAHSP90AA1L3MBTL1ALDH1A1 | |
| SCHEMBL21221232 | 0.65 | NPC1 (0.47) | MAPTLMNAL3MBTL1ALDH1A1HSD17B10 | |
| SCHEMBL19782984 | 0.64 | ADAMTS5 (0.52) | MAPTL3MBTL1ADAMTS4MMP14ADAMTS13 | |
| SCHEMBL19783018 | 0.62 | ADAMTS5 (0.50) | MAPTL3MBTL1ADAMTS4MMP14ADAMTS13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018013508-A1 | SUBSTITUTED AMINOTHIAZOLES | BARUCH S. BLUMBERG INSTITUTE (US) | 2018-01-18 | — | — | WO | disclosed |