Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19783110 | 0.80 | LMNA (0.35) | LMNAALDH1A1HPGDALOX5KDM4E | |
| SCHEMBL19783004 | 0.80 | LMNA (0.34) | LMNAALDH1A1HPGDALOX5KDM4E | |
| SCHEMBL19783003 | 0.78 | ADORA3 (0.41) | LMNAALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL19782897 | 0.74 | CDC7 (0.38) | ALDH1A1HPGDKDM4ESMN1; SMN2KMT2A | |
| SCHEMBL15993672 | 0.73 | LMNA (0.38) | LMNAALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL19782716 | 0.73 | CDC7 (0.39) | LMNAALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL19782898 | 0.70 | ALDH1A1 (0.39) | LMNAALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL19782724 | 0.69 | CDC7 (0.33) | ALDH1A1HPGDKDM4EKMT2ANPC1 | |
| SCHEMBL18236334 | 0.68 | ALDH1A1 (0.69) | LMNAALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL3403482 | 0.68 | LMNA (0.62) | LMNAALDH1A1HPGDKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018013508-A1 | SUBSTITUTED AMINOTHIAZOLES | BARUCH S. BLUMBERG INSTITUTE (US) | 2018-01-18 | — | — | WO | disclosed |