Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | F2RL3 | Q96RI0 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19783486 | 0.86 | STAT3 (0.41) | STAT3HTTSMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL19783468 | 0.78 | F2RL3 (0.69) | STAT3HTTSMN1; SMN2F2RL3ALDH1A1 | |
| SCHEMBL30189527 | 0.78 | F2RL3 (0.69) | STAT3HTTSMN1; SMN2F2RL3ALDH1A1 | |
| SCHEMBL19776972 | 0.76 | F2RL3 (0.46) | F2RL3 | |
| SCHEMBL610046 | 0.72 | L3MBTL1 (0.51) | STAT3HTTSMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL22980373 | 0.71 | GABRG2 (0.42) | STAT3HTTSMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL12157689 | 0.71 | ALDH1A1 (0.51) | STAT3HTTSMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL10481838 | 0.70 | MAPT (0.50) | STAT3HTTSMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL4265760 | 0.69 | CYP11B2 (0.48) | SMN1; SMN2L3MBTL1MAPTNUDT1GABRP | |
| SCHEMBL23213780 | 0.69 | L3MBTL1 (0.47) | STAT3HTTSMN1; SMN2L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018013774-A1 | BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-01-18 | — | — | WO | disclosed |