Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 3/20 | 0.48 |
| ▸ | CCND1 | P24385 | 3/20 | 0.48 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.48 |
| ▸ | CDK1 | P06493 | 2/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.48 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23223975 | 0.79 | KMT2A (0.47) | CDK4CCND1CCNB2CDK1CCNB1 | |
| SCHEMBL22839931 | 0.74 | XDH (0.35) | CDK4CCND1CCNB2CDK1CCNB1 | |
| SCHEMBL24404482 | 0.74 | HDAC1 (0.38) | CDK4CCND1CCNB2CDK1CCNB1 | |
| SCHEMBL22504653 | 0.73 | CDK4 (0.43) | CDK4CCND1CCNB2CDK1CCNB1 | |
| SCHEMBL19692666 | 0.67 | TRPM8 (0.51) | LTA4HPLA2G2ATRPM8MAPTSMN1; SMN2 | |
| SCHEMBL3917911 | 0.67 | LTA4H (0.48) | LTA4HPLA2G2ATRPM8SMN1; SMN2 | |
| SCHEMBL3906735 | 0.66 | CDK4 (1.00) | CDK4CCND1CCNB2CDK1CCNB1 | |
| SCHEMBL7272039 | 0.66 | CDK4 (1.00) | CDK4CCND1CCNB2CDK1CCNB1 | |
| SCHEMBL1412912 | 0.66 | HTR1A (0.73) | LTA4HPLA2G2ATRPM8MAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL19692661 | 0.66 | LTA4H (0.50) | LTA4HPLA2G2ATRPM8MAPTHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3383867-B1 | COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY | CHIESI FARM SPA (IT) | 2021-04-14 | — | — | EP | disclosed |
| WO-2018011090-A1 | HYDROXYQUINOLINONE COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY | CHIESI FARMACEUTICI S.P.A. (IT) | 2018-01-18 | — | — | WO | disclosed |