SCHEMBL1978459

SCHEMBL1978459

CCOC(=O)c1cnc([N+](=O)[O-])n1C

nearest known ligand 0.47

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAPT P10636 9/20 0.47
POLB P06746 1/20 0.47
MITF O75030 1/20 0.46
ALDH1A1 P00352 2/20 0.45
AR P10275 2/20 0.43
HTT P42858 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
KMT2A Q03164 1/20 0.41
LMNA P02545 1/20 0.41
KDM4E B2RXH2 1/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.40
IDO1 P14902 1/20 0.40
PTGS1 P23219 1/20 0.40
PTGS2 P35354 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30893642 0.90 MITF (0.43) MAPTPOLBMITFALDH1A1AR
SCHEMBL28881823 0.83 MAPT (0.54) MAPTPOLBALDH1A1L3MBTL1KMT2A
SCHEMBL25106583 0.82 MITF (0.43) MAPTPOLBMITFALDH1A1HTT
SCHEMBL25106760 0.80 MITF (0.41) MAPTPOLBMITFALDH1A1AR
SCHEMBL28720076 0.78 IDO1 (0.45) MAPTALDH1A1L3MBTL1KMT2ALMNA
SCHEMBL1993428 0.78 ENO1 (0.37) MAPTPOLBMITFALDH1A1AR
SCHEMBL11776821 0.78 LMNA (0.40) MAPTMITFALDH1A1LMNAKDM4E
SCHEMBL998243 0.75 IDO1 (0.43) KMT2ALMNAKDM4ENPC1RAB9A
SCHEMBL28616856 0.75 IDO1 (0.47) MAPTALDH1A1KMT2ALMNAKDM4E
SCHEMBL1979899 0.75 CSNK1D (0.49) MAPTPOLBALDH1A1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116583303-B Tripterine conjugates and uses thereof 瑞阳公司 2026-05-12 CN disclosed
EP-4654966-A1 METHODS AND COMPOSITIONS FOR TREATMENT OF OBESITY AND DISEASES ASSOCIATED WITH FAT CELL ENLARGEMENT MELLICELL, INC. (US) 2025-12-03 EP disclosed
WO-2025056913-A1 COMPOUND AND METHOD OXFORD UNIVERSITY INNOVATION LIMITED (GB) 2025-03-20 WO disclosed
CN-118955393-A 2, 4-Dinitrophenoxy compound and preparation method thereof 江南大学 2024-11-15 CN disclosed
US-12115226-B2 Linker containing arylnitro, antibody-drug conjugate containing linker and use of linker ACADEMY OF MILITARY MEDICAL SCIENCES (CN) 2024-10-15 US disclosed
WO-2024159211-A1 METHODS AND COMPOSITIONS FOR TREATMENT OF OBESITY AND DISEASES ASSOCIATED WITH FAT CELL ENLARGEMENT MELLICELL, INC. (US) 2024-08-02 WO disclosed
CN-118206492-A 2, 4-Dinitrophenoxy compound and preparation method thereof 江南大学 2024-06-18 CN disclosed
CN-117756848-A TH-302 derivative and preparation method thereof 常州大学 2024-03-26 CN disclosed
CN-115745975-B JAK kinase domain and pseudokinase domain co-inhibition prodrug, preparation method and medical application 中国药科大学 2023-11-24 CN disclosed
US-20230303618-A1 TRIPTOLIDE CONJUGATES AND USES THEREOF REYOUNG CORPORATION (US) 2023-09-28 US disclosed
EP-1896040-A2 PHOSPHORAMIDATE ALKYLATOR PRODRUGS Threshold Pharmaceuticals, Inc. (US) 2008-03-12 EP disclosed
WO-2007002931-A2 PHOSPHORAMIDATE ALKYLATOR PRODRUGS THRESHOLD PHARMACEUTICALS, INC. (US) 2007-01-04 WO disclosed
WO-2007002931-A2 PHOSPHORAMIDATE ALKYLATOR PRODRUGS THRESHOLD PHARMACEUTICALS, INC. (US) 2007-01-04 WO disclosed
EP-1622608-A2 COMPOSITIONS AND METHODS FOR TREATING CANCER Threshold Pharmaceuticals, Inc. (US) 2006-02-08 EP disclosed
WO-2004087075-A2 COMPOSITIONS AND METHODS FOR TREATING CANCER THRESHOLD PHARMACEUTICALS, INC. (US) 2004-10-14 WO disclosed
EP-1173414-A1 N-PROTECTED AMINES AND THEIR USE AS PRODRUGS CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) 2002-01-23 EP disclosed
WO-2000064864-A9 N-PROTECTED AMINES AND THEIR USE AS PRODRUGS CANCER RES CAMPAIGN TECH (GB) 2001-12-27 WO disclosed
WO-2000064864-A1 N-PROTECTED AMINES AND THEIR USE AS PRODRUGS CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) 2000-11-02 WO disclosed
US-3987053-A ANTIMICROBIAL GRUPPO LEPETIT S.P.A. (IT) 1976-10-19 US disclosed
US-3954789-A 2-Nitroimidazole derivatives GRUPPO LEPETIT S.P.A. (IT) 1976-05-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12115226-B2 Linker containing arylnitro, antibody-drug conjugate containing linker and use of linker BCR, FCGR2A, FCGRT MAPT 99/4885POLB 2563/4885MITF 3422/4885
US-20230303618-A1 TRIPTOLIDE CONJUGATES AND USES THEREOF TLR9, XIAP, ENPP2 MAPT 2281/4885POLB 3973/4885MITF 3065/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.